Unlocking the potential of metagenomics through replicated experimental design.
Unlocking the potential of metagenomics through replicated experimental design.
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DOI：
10.1038/nbt.2235
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发表时间：
2012-06-07
影响因子：
46.9
通讯作者：
Gilbert JA
中科院分区：
文献类型：
--
作者：
Knight R;Jansson J;Field D;Fierer N;Desai N;Fuhrman JA;Hugenholtz P;van der Lelie D;Meyer F;Stevens R;Bailey MJ;Gordon JI;Kowalchuk GA;Gilbert JA
宏基因组学为发现新的酶和生物体提供了巨大的希望，这些酶和生物体是疾病、工业和环境相关过程的生物标志物或原因。在过去的两年里，我们已经看到了宏基因组学的范式转变，应用广泛的横截面和纵向研究，使DNA测序和高性能计算的进步。这些技术现在使得广泛评估微生物多样性和功能成为可能，从而可以对微生物生命的基本未开发的前沿进行系统研究。为了实现这一目标，全球科学界必须开展合作，商定共同目标和数据标准，以便能够对地球微生物组进行比较研究。提高数据的可比性将有助于研究与生物技术有关的过程，如对新的糖苷水解酶进行生物勘探或确定新的能源。
Metagenomics holds enormous promise for discovering novel enzymes and organisms that are biomarkers or causes of processes relevant to disease, industry and the environment. In the last two years we have seen a paradigm shift in metagenomics to the application of broad cross-sectional and longitudinal studies enabled by advances in DNA sequencing and high-performance computing. These technologies now make it possible to broadly assess microbial diversity and function, allowing systematic investigation of the largely unexplored frontier of microbial life. To achieve this aim, the global scientific community must collaborate and agree upon common objectives and data standards to enable comparative research across the Earth’s microbiome. Improvements in comparability of data will facilitate the study of biotechnologically relevant processes such as bioprospecting for new glycoside hydrolases or identifying novel energy sources.