Hepatitis E Virus Mutations: Functional and Clinical Relevance.
Hepatitis E Virus Mutations: Functional and Clinical Relevance.
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DOI：
10.1016/j.ebiom.2016.07.039
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发表时间：
2016-09
期刊：
影响因子：
11.1
通讯作者：
Velavan, Thirumalaisamy P.
中科院分区：
文献类型：
--
作者：
Hoang van Tong;Nghiem Xuan Hoan;Wang, Bo;Wedemeyer, Heiner;Bock, C. -Thomas;Velavan, Thirumalaisamy P.
戊型肝炎病毒（HEV）感染是急性肝炎的一个主要原因，影响着2000多万人，全世界有300万例有症状病例和56,000例已确认的与HEV相关的死亡。戊型肝炎在发展中国家流行，由于本土病例数量的增加，在发达国家变得越来越重要。虽然HEV的复制受宿主免疫系统控制，但病毒因子（特别是特定的病毒基因型和突变体）可以调节HEV的复制、感染和发病机制。关于HEV基因组变异对发病机制、易感性和治疗反应的贡献的知识有限。非同义替换可以在结构上调节病毒蛋白，从而失调病毒与宿主的相互作用。本文综述了HEV异质性及其变异对病毒形态发生、发病机制、临床结局和抗病毒药物耐药性的影响。戊型肝炎引起急性肝炎，最近由于免疫功能低下患者持续感染而成为关注焦点。HEV变异性可能与临床发病机制和传播动力学有关。HEV基因组的突变可以影响HEV生理学和病毒与宿主的相互作用。HEV突变和变异性可能与暴发性肝衰竭和慢性戊型肝炎有关。RdRp结构域的Y1320H和G1634R/K突变通过增强HEV复制促进抗病毒抗性。我们检索了MEDLINE数据库和PubMed从1980年到2016年6月30日的文章。以不同组合使用的搜寻词包括“戊型肝炎”、“戊型肝炎病毒”、“戊型肝炎病毒感染”、“戊型肝炎病毒突变”、“戊型肝炎病毒变异性”、“戊型肝炎病毒耐药性”、“戊型肝炎病毒复制”及“利巴韦林”。从这些检索中得到的文章和这些文章中引用的相关参考文献根据其相关主题进行选择并进行审查。会议的摘要和报告也包括在内。以英文发表的文章也包括在内。
Hepatitis E virus (HEV) infection is a major cause of acute hepatitis and affects more than 20 million individuals, with three million symptomatic cases and 56,000 recognized HEV-related deaths worldwide. HEV is endemic in developing countries and is gaining importance in developed countries, due to increased number of autochthone cases. Although HEV replication is controlled by the host immune system, viral factors (especially specific viral genotypes and mutants) can modulate HEV replication, infection and pathogenesis. Limited knowledge exists on the contribution of HEV genome variants towards pathogenesis, susceptibility and to therapeutic response. Nonsynonymous substitutions can modulate viral proteins structurally and thus dysregulate virus-host interactions. This review aims to compile knowledge and discuss recent advances on the casual role of HEV heterogeneity and its variants on viral morphogenesis, pathogenesis, clinical outcome and antiviral resistance. HEV causes acute hepatitis and recently comes into focus because of persistent infection in immunocompromised patients. HEV variability can be associated with clinical pathogenesis and transmission dynamics. Mutations in the HEV genome can influence HEV physiology and virus-host interaction. HEV mutations and variability are likely associated with fulminant hepatic failure and chronic hepatitis E. The Y1320H and G1634R/K mutations in the RdRp domain contribute to antiviral resistance through enhancing HEV replication. We searched MEDLINE database and PubMed for articles from 1980 through June 30, 2016. Search terms used in various combinations were “hepatitis E”, “hepatitis E virus”, “hepatitis E virus infection”, “hepatitis E virus mutation”, “HEV variability”, “HEV genotype”, “HEV drug resistance”, “HEV replication” and “ribavirin”. Articles resulting from these searches and relevant references cited in those articles were selected based on their related topics and were reviewed. Abstracts and reports from meetings were also included. Articles published in English were included.
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影响因子：
0.6
作者：
Geng Y;Zhang H;Huang W;J Harrison T;Geng K;Li Z;Wang Y
通讯作者：
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影响因子：
2.5
作者：
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影响因子：
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Meng, Xiang-Jin
DOI：
10.1073/pnas.251555098
发表时间：
2001-12-18
影响因子：
11.1
作者：
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通讯作者：
Purcell, RH
影响因子：
5.4
作者：
Ahola, T;den Boon, JA;Ahlquist, P
通讯作者：
Ahlquist, P