Reversible weakness and encephalopathy while on long-term valproate treatment due to carnitine deficiency.
Reversible weakness and encephalopathy while on long-term valproate treatment due to carnitine deficiency.
复制标题
DOI：
10.1136/bcr-2015-210727
复制
发表时间：
2015-09-02
期刊：
影响因子：
0.9
通讯作者：
Bilous, Rudy
中科院分区：
文献类型：
--
作者：
Al-sharefi, Ahmed;Bilous, Rudy
我们描述了一例35岁女性患者，在长期丙戊酸盐治疗期间出现双侧下肢无力和脑病。她被诊断为由于肉毒碱缺乏引起的丙戊酸盐诱导的脑病。临床改善发生与口服肉毒碱补充。我们的病例报告强调了在长期丙戊酸盐治疗期间出现不明原因神经系统体征的患者中考虑肉毒碱缺乏的重要性。
We describe a case of a 35-year-old woman who presented with bilateral leg weakness and encephalopathy while on long-term valproate therapy. She was diagnosed with valproate-induced encephalopathy due to carnitine deficiency. Clinical improvement occurred with oral carnitine supplementation. Our case report highlights the importance of considering carnitine deficiency in patients presenting with unexplained neurological signs while on long-term valproate treatment.