E-Cigarette Use and Adult Cigarette Smoking Cessation: A Meta-Analysis
E-Cigarette Use and Adult Cigarette Smoking Cessation: A Meta-Analysis
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DOI：
10.2105/ajph.2020.305999
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发表时间：
2021-02-01
影响因子：
12.7
通讯作者：
Glantz, Stanton A.
中科院分区：
文献类型：
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作者：
Wang, Richard J.;Bhadriraju, Sudhamayi;Glantz, Stanton A.
目标。确定电子烟的使用与戒烟之间的关系。我们检索了PubMed、Web of Science Core Collection和EMBASE，并使用随机效应Meta分析计算了电子烟使用与戒烟的关联。我们确定了论文(55项观察性研究和9项随机临床试验[RCT])。在对所有成年吸烟者(优势比[OR]=0.947；95%可信区间[CI]=0.772，1.160)和有戒烟动机的吸烟者(OR=0.851；95%CI=0.684，1.057)的观察性研究中，电子烟消费品的使用与戒烟无关。每天使用电子烟与较多戒烟相关(OR=1.529；95%CI=1.158，2.019)，每天使用较少电子烟与较少戒烟相关(OR=0.514；95%CI=0.402，0.665)。随机对照试验比较了提供电子烟和常规治疗的吸烟者的戒烟情况，发现使用电子烟与更多的戒烟有关(相对风险=1.555；95%CI=1.173，2.061)。作为消费产品，在观察性研究中，电子烟与成年人戒烟人数的增加无关。在随机对照试验中，提供免费电子烟作为治疗干预与增加戒烟有关。对公共卫生的影响。电子烟不应被批准为消费品，但可能值得考虑作为一种处方药。
Objectives. To determine the association between e-cigarette use and smoking cessation.Methods. We searched PubMed, Web of Science Core Collection, and EMBASE and computed the association of e-cigarette use with quitting cigarettes using random effects meta-analyses.Results. We identified 64 papers (55 observational studies and 9 randomized clinical trials [RCTs]). In observational studies of all adult smokers (odds ratio [OR] = 0.947; 95% confidence interval [CI] = 0.772, 1.160) and smokers motivated to quit smoking (OR = 0.851; 95% CI = 0.684, 1.057), e-cigarette consumer product use was not associated with quitting. Daily e-cigarette use was associated with more quitting (OR = 1.529; 95% CI = 1.158, 2.019) and less-than-daily use was associated with less quitting (OR = 0.514; 95% CI = 0.402, 0.665). The RCTs that compared quitting among smokers who were provided e-cigarettes to smokers with conventional therapy found e-cigarette use was associated with more quitting (relative risk = 1.555; 95% CI = 1.173, 2.061).Conclusions. As consumer products, in observational studies, e-cigarettes were not associated with increased smoking cessation in the adult population. In RCTs, provision of free e-cigarettes as a therapeutic intervention was associated with increased smoking cessation. Public Health Implications. E-cigarettes should not be approved as consumer products but may warrant consideration as a prescription therapy.