microRNA-510-5p promotes thyroid cancer cell proliferation, migration, and invasion through suppressing SNHG15
microRNA-510-5p promotes thyroid cancer cell proliferation, migration, and invasion through suppressing SNHG15
复制标题
microRNA-510-5p通过抑制SNHG15促进甲状腺癌细胞增殖、迁移和侵袭
DOI：
10.1002/jcb.28454
复制
发表时间：
2019-07-01
影响因子：
4
通讯作者：
Wu, Liping
中科院分区：
文献类型：
--
作者：
Liu, Yongcun;Li, Junli;Wu, Liping
SNHG15 has been suggested to be correlated with clinical progression and prognosis, and function as tumor suppressive long noncoding RNA in thyroid cancer at our previous study. SNHG15 was proposed to be a potential target for miR-510-5p at LncBase Predicted database. Thus, the aim of this study was to explore the relationship between miR-510-5p and SNHG15 in thyroid cancer, and the clinical significance of miR-510-5p in patients with thyroid cancer. In our results, levels of miR-510-5p expression were increased in thyroid cancer tissues and cell lines compared with adjacent normal thyroid tissues and normal thyroid cell line, respectively. There was a statistically negative correlation between SNHG15 expression and miR-510-5p expression in thyroid cancer tissues. Moreover, miR-510-5p directly bound to SNHG15, and negatively regulated SNHG15 expression in thyroid cancer cells. Furthermore, miR-510-5p promoted thyroid cancer cell proliferation, migration, and invasion through suppressing SNHG15. Finally, high miR-510-5p expression was observed in tumor tissues with advanced clinical stage or lymph node metastasis. In conclusion, we provide evidence to support a pivotal role for miR-510-5p in regulating thyroid cancer cell proliferation, migration, and invasion.
