Insulin sensitivity in pre-eclampsia
Insulin sensitivity in pre-eclampsia
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DOI：
10.1111/j.1471-0528.1998.tb09942.x
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发表时间：
1998-10-01
期刊：
影响因子：
--
通讯作者：
Hadden, DR
中科院分区：
文献类型：
--
作者：
Roberts, RN;Henriksen, JE;Hadden, DR
Objective To investigate whether pre-eclampsia is associated with an exaggeration of the insulin resistance seen in normotensive pregnancy.Design Minimal model analysis of a frequently sampled intravenous glucose tolerance test to assess insulin sensitivity.Setting Royal Maternity Hospital, Belfast.Participants Eleven women with pre-eclampsia and 11 matched normotensive pregnant women.Results Insulin sensitivity (S-I) was increased in the group with pre-eclampsia compared with the normotensive women (mean [+/-SEM]: 2.6 [0.4] vs 1.6 [0.2] 10(-4) min(-1) per mU/L; P = 0.028). This was accompanied by a decrease in glucose effectiveness (S-G) (1.1 +/- 0.1 vs 1.7 +/- 0.1 10(-2) min(-1) P = 0.006) in the pre-eclamptic women. In the normotensive group there was a significant inverse correlation between S-I and mean arterial blood pressure (r = -0.65; P = 0.03), but no such relation existed in the group with pre-eclampsia.Conclusions As with other forms of secondary hypertension, and unlike essential hypertension, the pathophysiology of pre-eclampsia is not associated with insulin resistance.
