Pneumococcal superinfection in COVID-19 patients: A series of 5 cases
Pneumococcal superinfection in COVID-19 patients: A series of 5 cases
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DOI：
10.1016/j.medcli.2020.05.022
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发表时间：
2020-12-11
期刊：
影响因子：
3.9
通讯作者：
Nicolas, David
中科院分区：
文献类型：
--
作者：
Cucchiari, David;Pericas, Juan M.;Nicolas, David
背景：在COVID-19大流行的背景下，其他呼吸道感染原因的误诊风险很可能存在。在这项工作中，我们的目的是描述肺炎球菌感染的COVID-19 patients.Patients和方法的临床特征，治疗和结果：每个COVID-19患者在2020年3月期间在西班牙巴塞罗那的三级教学医院出现伴随肺炎球菌肺炎。所有病例胸部X线均异常，有单侧或双侧浸润。事实证明，前降钙素不够敏感，无法检测肺炎球菌感染。抗生素治疗，及时开始在所有5例随后令人满意的evolution.Conclusion：国际指南不包括细菌合并感染的普遍筛查。COVID-19的放射学模式与肺炎球菌肺炎的放射学模式无法区分，并且合并感染的频率尚未完全确定，因此临床医生应了解可能的SARS-CoV-2-肺炎球菌相关性，以避免误诊和延误抗生素治疗。(c)2020 Elsevier Espana，S.L.U. All rights reserved.
Background: In the context of the COVID-19 pandemic the risk of misdiagnosis of other causes of respiratory infection is likely. In this work we aim to describe the clinical characteristics, treatment and outcome of pneumococcal infection in COVID-19 patients.Patients and methods: Every COVID-19 patient presenting with concomitant pneumococcal pneumonia during March 2020 in a tertiary teaching Hospital In Barcelona, Spain.Results: Five patients with PCR confirmed COVID19 or clinical and radiological suspicion were diagnosed of pneumococcal infection. In all cases chest X-ray were abnormal, with unilateral or bilateral infiltrates. Procalcitonin showed to be not sensitive enough to detect pneumococcal infection. Antibiotherapy was promptly started in all five cases with subsequent satisfactory evolution.Conclusion: International guidelines do not include the universal screening for bacterial co-infection. Radiological pattern of COVID-19 can be indistinguishable from that of pneumococcus pneumonia and frequency of co-infection is not well stablished, therefore clinicians should be aware of the possible SARS-CoV-2-pneumococcus association to avoid misdiagnosis and delay antibiotic therapy. (c) 2020 Elsevier Espana, S.L.U. All rights reserved.