Pharmacological evidence for GABA as the transmitter in granule cell inhibition in the olfactory bulb.
Pharmacological evidence for GABA as the transmitter in granule cell inhibition in the olfactory bulb.
复制标题
GABA 作为嗅球颗粒细胞抑制递质的药理学证据。
DOI：
10.1016/0006-8993(71)90600-7
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发表时间：
1971
期刊：
影响因子：
2.9
通讯作者：
R. Nicoll
中科院分区：
文献类型：
--
作者：
R. Nicoll
惊厥剂印防己毒素和荷包牡丹碱阻断微量注射GABA的兴奋作用，士的宁选择性阻断甘氨酸对嗅球僧帽细胞的兴奋作用。氨基酸，d，l-同型半胱氨酸（DLH），谷氨酸和天冬氨酸，兴奋几乎所有其他中枢神经元，往往抑制二尖瓣细胞，这种效果被Mg 2+阻断。兴奋性氨基酸产生的抑制作用可被印防己毒素和荷包牡丹碱逆转为兴奋作用。这些结果是一致的建议，颗粒细胞突触抑制二尖瓣细胞是由GABA介导的。然而，颗粒细胞抑制引起的生理，证明难以拮抗与惊厥，但在某些情况下，可以证明一定程度的拮抗作用。结果提示GABA可能是颗粒细胞释放的抑制性递质。
The convulsants picrotoxin and bicuculline block the depressant action of microelectrophoretically administered GABA and strychnine selectively blocks the depressant action of glycine on olfactory bulb mitral cells. The amino acids,d,l-homocysteate (DLH), glutamate, and aspartate, which excite virtually all other central neurons, often inhibited mitral cells and this effect was blocked by Mg2+. The depression produced by excitant amino acids is reversed to excitation by picrotoxin and bicuculline. These results are consistent with the proposal that granule cell synaptic inhibition of mitral cells is mediated by GABA. The granule cell inhibition elicited physiologically, however, proved difficult to antagonize with convulsants, but in some cases a degree of antagonism could be demonstrated. The results suggest that GABA may be the inhibitory transmitter released by granule cells.