Assessment of vitamin C and Antioxidant Profiles in Saliva and Serum in Patients with Periodontitis and Ischemic Heart Disease
Assessment of vitamin C and Antioxidant Profiles in Saliva and Serum in Patients with Periodontitis and Ischemic Heart Disease
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DOI：
10.3390/nu11122956
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发表时间：
2019-12-01
期刊：
影响因子：
5.9
通讯作者：
Lo Giudice, Antonino
中科院分区：
文献类型：
--
作者：
Isola, Gaetano;Polizzi, Alessandro;Lo Giudice, Antonino
维生素C和抗氧化剂在内皮功能中起关键作用，并且可能是牙周炎和缺血性心脏病（CAD）的已知相互作用的联系。这项初步研究评估了牙龈健康、牙周炎、CAD或这两种疾病与唾液和血清维生素C和抗氧化剂水平的关系。收集了36例牙周炎患者、35例CAD患者、36例牙周炎合并CAD患者和36例健康对照者的临床和牙周特征、血清和唾液样本。维生素C、抗氧化剂和C-反应蛋白（hs-CRP）水平用市售试剂盒进行评估。与牙周炎患者和对照组相比，CAD组（p < 0.001）和牙周炎合并CAD组（p <0.001）的唾液和血清维生素C和抗氧化剂（α-生育酚、β-胡萝卜素、叶黄素和番茄红素）的中位浓度显著降低。在单变量模型中，牙周炎（p = 0.034）、CAD（p < 0.001）和hs-CRP（p <0.001）与血清维生素C显著负相关;而在多变量模型中，只有hs-CRP仍然是血清维生素C的显著预测因子（p < 0.001）。在多变量模型中，唾液维生素C水平的显著预测因子是甘油三酯（p = 0.028）和hs-CRP（p < 0.001）。与健康受试者和牙周炎患者相比，CAD和牙周炎加CAD患者的唾液和血清维生素C水平较低。hs-CRP是唾液和血清维生素C水平降低的重要预测因子。
vitamin C and antioxidants play a crucial role in endothelial function and may be a link for the known interaction of periodontitis and ischemic heart disease (CAD). This pilot study evaluates the association of gingival health, periodontitis, CAD, or both conditions with salivary and serum vitamin C and antioxidant levels. The clinical and periodontal characteristics, serum, and saliva samples were collected from 36 patients with periodontitis, 35 patients with CAD, 36 patients with periodontitis plus CAD, and 36 healthy controls. Levels of vitamin C, antioxidants, and C-reactive protein (hs-CRP) were assessed with a commercially available kit. The median concentrations of salivary and serum vitamin C and antioxidants (alpha-tocopherol, beta-carotene, lutein, and lycopene) were significantly lower in the CAD group (p < 0.001) and in the periodontitis plus CAD group (p < 0.001) compared to periodontitis patients and controls. In univariate models, periodontitis (p = 0.034), CAD (p < 0.001), and hs-CRP (p < 0.001) were significantly negatively associated with serum vitamin C; whereas, in a multivariate model, only hs-CRP remained a significant predictor of serum vitamin C (p < 0.001). In a multivariate model, the significant predictors of salivary vitamin C levels were triglycerides (p = 0.028) and hs-CRP (p < 0.001). Patients with CAD and periodontitis plus CAD presented lower levels of salivary and serum vitamin C compared to healthy subjects and periodontitis patients. hs-CRP was a significant predictor of decreased salivary and serum vitamin C levels.