The feasibility of using thermal strain imaging to regulate energy delivery during intracardiac radio-frequency ablation.
The feasibility of using thermal strain imaging to regulate energy delivery during intracardiac radio-frequency ablation.
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DOI：
10.1109/tuffc.2011.1960
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发表时间：
2011-07
期刊：
影响因子：
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通讯作者：
O'Donnell M
中科院分区：
文献类型：
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作者：
Seo CH;Stephens DN;Cannata J;Dentinger A;Lin F;Park S;Wildes D;Thomenius KE;Chen P;Nguyen T;de La Rama A;Jeong JS;Mahajan A;Shivkumar K;Nikoozadeh A;Oralkan O;Truong U;Sahn DJ;Khuri-Yakub PT;O'Donnell M
介绍了一种通过检查声速随温度变化引起的热应变曲线斜率变化来监测心脏消融治疗的方法。含水组织（如心肌）的声速随着温度的升高而增加。然而，在高于约50°C的温度下，声速没有进一步增加，温度系数可能会变得稍微为负。对于消融治疗，根据众所周知的Arrhenius方程，在48 ° C至50°C的范围内短时间内发生对组织的不可逆损伤和完全心脏传导阻滞。使用这两个属性，我们提出了一个潜在的工具来检测的时刻，当组织损伤发生时，通过使用减少的斜率在热应变曲线作为加热时间的函数。我们已经说明了这种方法的可行性，初步使用猪心肌在体外。该方法进一步证明在体内，使用专门配备的消融尖端和11 MHz微线性心内超声心动图（ICE）阵列安装在导管的尖端。热应变曲线显示出平台，强烈表明温度达到至少50°C。
A method is introduced to monitor cardiac ablative therapy by examining slope changes in the thermal strain curve caused by speed of sound variations with temperature. The sound speed of water-bearing tissue such as cardiac muscle increases with temperature. However, at temperatures above about 50°C, there is no further increase in the sound speed and the temperature coefficient may become slightly negative. For ablation therapy, an irreversible injury to tissue and a complete heart block occurs in the range of 48 to 50°C for a short period in accordance with the well-known Arrhenius equation. Using these two properties, we propose a potential tool to detect the moment when tissue damage occurs by using the reduced slope in the thermal strain curve as a function of heating time. We have illustrated the feasibility of this method initially using porcine myocardium in vitro. The method was further demonstrated in vivo, using a specially equipped ablation tip and an 11-MHz microlinear intracardiac echocardiography (ICE) array mounted on the tip of a catheter. The thermal strain curves showed a plateau, strongly suggesting that the temperature reached at least 50°C.