Secondary hyperparathyroidism in chronic renal failure. The clinical spectrum in uremia, during hemodialysis, and after renal transplantation.
Secondary hyperparathyroidism in chronic renal failure. The clinical spectrum in uremia, during hemodialysis, and after renal transplantation.
复制标题
慢性肾功能衰竭继发性甲状旁腺功能亢进。
DOI：
10.1001/archinte.1969.00300200043008
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发表时间：
1969
影响因子：
--
通讯作者：
C. Kleeman
中科院分区：
文献类型：
--
作者：
S. Massry;J. Coburn;M. Popovtzer;J. Shinaberger;M. Maxwell;C. Kleeman
甲状旁腺增生和高水平的循环甲状旁腺激素在慢性肾功能衰竭患者中很常见，甚至在轻度肾功能损害患者中也是如此。然而，显性甲状旁腺功能亢进综合征在这些患者中并不常见。随着慢性肾功能衰竭患者寿命的延长，明显甲状旁腺功能亢进的发生频率越来越高。导致甲状旁腺增生和亢进的过程背后的确切致病因素，显性甲状旁腺功能亢进并不总是存在的原因，该实体的临床和生化标准，以及慢性尿毒症患者在血液透析期间和肾移植后甲状旁腺的功能特征尚未明确描述3,4在本报告中，甲状旁腺功能亢进一词被用来指一种具有一定临床、x线和生化表现的综合征
Hyperplasia of the parathyroid glands and high levels of circulating parathyroid hormone are common in patients with chronic renal failure,1and even in those with mild impairment of renal function.2However, the syndrome of overt hyperparathyroidism is not frequently seen in these patients. With the prolongation of the life of patients with chronic renal failure, overt hyperparathyroidism is being observed with increasing frequency. The exact pathogenetic factors which underlie the dynamics of the processes leading to hyperplasia and hyperactivity of the parathyroid glands, the reasons why overt hyperparathyroidism is not always present, the clinical and biochemical criteria of this entity, and the functional characteristics of the parathyroid glands in patients with chronic uremia during hemodialysis and after renal transplant are as yet not clearly delineated.3,4 In this report, the term hyperparathyroidism is used to indicate a syndrome with certain clinical, roentgenographic, and biochemical manifestations which are observed