4-hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain
4-hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain
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DOI：
10.1016/s0378-8741(00)00313-5
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发表时间：
2000-11-01
影响因子：
5.4
通讯作者：
Huh, K
中科院分区：
文献类型：
--
作者：
Ha, JH;Lee, DU;Huh, K
G, elata 甲醇提取物的醚部分显着抑制戊四唑 (PTZ) 治疗引起的恢复时间和严重程度。对 PTZ 处理的大鼠进行亚惊厥剂量时，用 G. elata 甲醇提取物的乙醚部分进行预处理，成功防止了脑 GABA 水平的降低。 4-羟基苯甲醛是对羟基苯甲醇的类似物，对GABA转氨酶表现出抑制作用，其抑制活性高于已知的抗惊厥药丙戊酸。在PTZ处理的大鼠大脑中，脑脂质过氧化显着增加，而用4-羟基苯甲醛处理后恢复到对照水平。可以得出结论，4-羟基苯甲醛的 GABA 能神经调节的抗氧化和正调节部分有助于 G. elata B1 的抗癫痫和抗惊厥活性。 (C) 2000 Elsevier Science Ireland Ltd. 保留所有权利。
Ether fraction of G, elata methanol extract significantly inhibited the recovery time and severity induced by pentylenetetrazole (PTZ) treatment. Pretreatment of ether fraction of G. elata methanol extract successfully prevented diminution of brain GABA level in subconvulsive dose of PTZ-treated rats. 4-Hydroxybenzaldehyde, an analogue of p-hydroxybenzyl alcohol, showed an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant. In the brain of PTZ-treated rats, brain lipid peroxidation was significantly increased, while it recovered to the control level after treatment with 4-hydroxybenzaldehyde. It may be concluded that anti oxidation and positive modulation of GABAergic neuromodulation of 4-hydroxybenzaldehyde partially contribute to an antiepileptic and anticonvulsive activity of G. elata B1. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.