Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys
Effects of ramelteon (TAK-375) on nocturnal sleep in freely moving monkeys
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雷美替胺 (TAK-375) 对自由活动的猴子夜间睡眠的影响
DOI：
10.1016/j.brainres.2004.08.035
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发表时间：
2004
期刊：
影响因子：
2.9
通讯作者：
M. Miyamoto
中科院分区：
文献类型：
--
作者：
N. Yukuhiro;H. Kimura;H. Nishikawa;S. Ohkawa;Shin;M. Miyamoto
我们研究了新型 MT1/MT2 受体激动剂 (S)-N-[2-(1,6,7,8-四氢-2H-茚并-[5,4]呋喃-8-基)乙基]丙酰胺（ramelteon，TAK-375）对自由活动的猴子夜间睡眠的影响，并将这些结果与褪黑激素和唑吡坦的结果进行了比较。雷美替胺（0.03 和 0.3 mg/kg，口服）治疗显着缩短了入睡潜伏期，并显着增加了总睡眠时间。褪黑激素（0.3、1 和 3 mg/kg，口服）治疗也可缩短睡眠潜伏期，但效果较弱；唯一显着的减少是在 0.3 mg/kg 剂量下观察到浅睡眠潜伏期。褪黑激素对睡眠持续时间没有显着影响。在本研究中，任何剂量（1、3、10 和 30 mg/kg，口服）的唑吡坦对入睡潜伏期均无显着影响。唑吡坦最高剂量（30 mg/kg）有增加慢波睡眠的趋势；然而，它也引起明显的镇静和肌肉松弛。雷美替胺和褪黑激素治疗对猴子的一般行为没有明显影响。雷美替胺和褪黑激素的光谱分析（快速傅立叶变换，FFT）显示，睡眠模式与自然发生的睡眠模式没有区别。唑吡坦的脑电图功率谱与自然发生的生理睡眠的脑电图功率谱有质的不同。本研究的结果支持了雷美替胺作为人类睡眠促进剂的研究。
We investigated the effects of (S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4]furan-8-yl)ethyl]propionamide (ramelteon, TAK-375), a novel MT1/MT2receptor agonist, on nocturnal sleep in freely moving monkeys and compared these results with those of melatonin and zolpidem. Treatment with ramelteon (0.03 and 0.3 mg/kg, p.o.) significantly shortened latency to sleep onset and significantly increased total duration of sleep. Treatment with melatonin (0.3, 1, and 3 mg/kg, p.o.) also decreased sleep latency, but the effect was weak; the only significant reduction was seen with the 0.3 mg/kg dose on latency to light sleep. Melatonin had no significant effects on the duration of sleep. Zolpidem had no significant effects on latency to sleep onset in this study at any dose (1, 3, 10, and 30 mg/kg, p.o.). The highest dose (30 mg/kg) of zolpidem had a tendency to increase slow wave sleep; however, it also induced apparent sedation and myorelaxation. Treatment with ramelteon and melatonin had no evident effect on the general behavior of the monkeys. Spectral analysis (fast Fourier transform, FFT) of both ramelteon and melatonin revealed sleep patterns that were indistinguishable from those of naturally occurring sleep. The EEG power spectra of zolpidem were qualitatively different from that of naturally occurring physiological sleep. Results of the present study support the investigation of ramelteon as a sleep-promoting agent in humans.
狒狒的唑吡坦行为药理学：自我注射、歧视、耐受和戒断。
DOI：
--
发表时间：
1992
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Griffiths,RR;Sannerud,CA;Ator,NA;Brady,JV
通讯作者：
Brady,JV
DOI：
10.1073/pnas.92.19.8734
发表时间：
1995-09-12
影响因子：
11.1
作者：
REPPERT, SM;GODSON, C;GUSELLA, JF
通讯作者：
GUSELLA, JF