Effect of coinfection with GB virus C on survival among patients with HIV infection.
Effect of coinfection with GB virus C on survival among patients with HIV infection.
复制标题
DOI：
10.1056/nejmoa003364
复制
发表时间：
2001-09-06
影响因子：
158.5
通讯作者：
Stapleton, JT
中科院分区：
文献类型：
--
作者：
Xiang, JH;W端nschmann, S;Stapleton, JT
背景资料：以前的研究表明，与GB病毒C（GBV-C，或庚型肝炎病毒）合并感染的人类免疫缺陷病毒（HIV）感染者延缓了HIV疾病的进展。GBV-C与丙型肝炎病毒有关，但似乎不会引起肝脏疾病。方法：我们研究了与GBV-C合并感染对HIV感染患者生存的影响。我们还评估了与这两种病毒感染的外周血单个核细胞的培养物，以确定是否GBV-C感染改变复制在vitro.Results：362 HIV感染的患者，144（39.8%）有GBV-C病毒血症在两个测试。在随访期间，41名GBV-C病毒血症患者（28.5%）死亡，而218名GBV-C RNA检测阴性的患者中有123名（56.4%; P
Background: Previous studies have suggested that people with human immunodeficiency virus (HIV) infection who are coinfected with GB virus C (GBV-C, or hepatitis G virus) have delayed progression of HIV disease. GBV-C is related to hepatitis C virus but does not appear to cause liver disease.Methods: We examined the effect of coinfection with GBV-C on the survival of patients with HIV infection. We also evaluated cultures of peripheral-blood mononuclear cells infected with both viruses to determine whether GBV-C infection alters replication in vitro.Results: Of 362 HIV-infected patients, 144 (39.8 percent) had GBV-C viremia in two tests. Forty-one of the patients with GBV-C viremia (28.5 percent) died during the follow-up period, as compared with 123 of the 218 patients who tested negative for GBV-C RNA (56.4 percent; P