Effects of chloroquine on viral infections: an old drug against today's diseases?
Effects of chloroquine on viral infections: an old drug against today's diseases?
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DOI：
10.1016/s1473-3099(03)00806-5
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发表时间：
2003-11
期刊：
影响因子：
--
通讯作者：
Cauda R
中科院分区：
文献类型：
--
作者：
Savarino A;Boelaert JR;Cassone A;Majori G;Cauda R
氯喹是自1934年以来已知的9-氨基喹啉。除了其众所周知的抗疟疾作用外，该药物还具有有趣的生化特性，可用于治疗某些病毒感染。氯喹发挥直接的抗病毒作用，抑制几种病毒的复制的pH依赖性步骤，包括黄病毒、逆转录病毒和冠状病毒的成员。它最好的研究效果是那些对艾滋病毒复制，这是在临床试验中测试。此外，氯喹具有免疫调节作用，抑制肿瘤坏死因子α和白细胞介素6的产生/释放，这些因子和白细胞介素6介导几种病毒性疾病的炎症并发症。我们回顾了现有的资料氯喹对病毒感染的影响，提出了这样一个问题，即这种古老的药物是否可能在病毒性疾病，如艾滋病和严重急性呼吸道综合征，在全球化时代折磨人类的临床管理中经历复兴。
Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor α and interleukin 6, which mediate the inflammatory complications of several viral diseases. We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.
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