Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study
Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study
复制标题
DOI：
10.1038/s41416-020-0789-7
复制
发表时间：
2020-03-17
影响因子：
8.8
通讯作者：
Cho, Jong Ho
中科院分区：
文献类型：
--
作者：
Jeon, Keun Hye;Shin, Dong Wook;Cho, Jong Ho
背景：研究假设绝经后妇女的生殖因素和激素使用会影响患肺癌的风险，但流行病学证据并不一致。方法利用韩国国家健康保险系统数据库，我们确定了4,775,398名40岁以上的绝经后妇女，她们在2009年1月1日至2014年12月31日期间接受了心血管健康和癌症筛查。有关生殖因素的信息是从自填式问卷中获得的。用COX比例风险回归模型估计肺癌的风险。结果在中位数4.4年的随访中，16,556名女性(15,223名非吸烟者)被诊断为肺癌。初潮早期年龄对肺癌的风险没有显著影响(调整后的初潮风险比=1.03：18比=55：55。
Background Reproductive factors and hormone use in postmenopausal women have been hypothesised to affect the risk of developing lung cancer, but the epidemiological evidence is inconsistent. Methods Using the Korean National Health Insurance System database, we identified 4,775,398 postmenopausal women older than 40 years who had undergone both cardiovascular health- and cancer screening between 1 January 2009 and 31 December 2014. Information about reproductive factors was obtained from a self-administered questionnaire. The risk of lung cancer was estimated using Cox proportional hazard regression models. Results During a median follow-up of 4.4 years, 16,556 women (15,223 non-smokers) were diagnosed with lung cancer. The risk of lung cancer was not significantly influenced by early menarche age (adjusted hazard ratio [aHR] 1.03 for menarche >= 18 vs. = 55 vs.