Assessment of dermal absorption and penetration of components of a fuel mixture (JP-8)
Assessment of dermal absorption and penetration of components of a fuel mixture (JP-8)
复制标题
DOI：
10.1016/s0048-9697(01)01111-1
复制
发表时间：
2002-04-08
影响因子：
9.8
通讯作者：
Robinson, PJ
中科院分区：
文献类型：
--
作者：
McDougal, JN;Robinson, PJ
职业和环境中的多种化学品接触极为普遍。评估皮肤接触复杂混合物的风险的方法因现有信息而异。挥发性混合物（如JP-8喷气燃料）的成分可能会发生根本性变化，这取决于混合物的相态-蒸汽，液体或气溶胶。评估混合物成分的吸收（进入皮肤）和渗透（通过皮肤）可减少风险评估过程中的不确定性。可检测到渗透皮肤的12种单独组分的渗透系数可用于评估JP-8中每种单独组分的毒性。这些组分中的每一种的渗透与该组分的分子量和辛醇-水分配系数相关，并且可以从该组分的分子量和辛醇-水分配系数预测。渗透皮肤的组分的组成将不同于JP-8的组成，因为组分的渗透性相差两个数量级。在皮肤中发现的脂肪族化学物质的浓度与碳数良好相关。JP-8喷气燃料用作关于吸收和渗透的组分数据如何可以被整合到评估中的示例（McDougal等人，Toxicol Sci 2000; 55：247-255）。组分法显示出估计混合物全身毒性的前景。局部毒性（刺激、致敏等）今后，当能够获得关于造成局部影响所需的化学品接触的持续时间和程度的定量信息时，可能会更好地理解这一点。(C)2002 Elsevier Science B. V.保留所有权利。
Occupational and environmental multi-chemical exposures are extremely common. Methods for assessment of the risks from dermal exposures to complex mixtures vary depending on the information available. The composition of a volatile mixture (such as JP-8 jet fuel) can change radically, depending on the phase of the mixture - vapor, liquid or aerosol. Assessing the absorption (into the skin) and penetration (through the skin) of components of the mixture can reduce uncertainty in the risk assessment process. Permeability coefficients of the 12 individual components that could be detected to penetrate the skin could be used to assess the toxicity of each individual component in the JP-8. The penetration of each of these components is related to and can be predicted from molecular weight and octanol water partition coefficients of that component. The composition of the components that penetrate the skin would be different from the composition of JP-8 because the permeability of the components differs by two orders of magnitude. Concentrations of the aliphatic chemicals found in the skin correlated well with carbon number, The JP-8 jet fuel is used as an example of how component data on absorption and penetration can be integrated into an assessment (McDougal et al., Toxicol Sci 2000; 55: 247-255). The component approach shows promise for estimating systemic toxicity of mixtures. Local toxicity (irritation, sensitization, etc.) may be better understood in the future when quantitative information becomes available about the duration and magnitude of chemical exposures required to cause local effects. (C) 2002 Elsevier Science B.V. All rights reserved.