Role of FEF25%-75% as a predictor of bronchial hyperreactivity in allergic patients
Role of FEF25%-75% as a predictor of bronchial hyperreactivity in allergic patients
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DOI：
10.1016/s1081-1206(10)61067-8
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发表时间：
2006-05-01
影响因子：
5.9
通讯作者：
Ciprandi, Giorgio
中科院分区：
文献类型：
--
作者：
Cirillo, Ignazio;Klersy, Catherine;Ciprandi, Giorgio
背景：小气道可能在哮喘的临床表现中起重要作用。用力呼气流量25%-75%（FEF25%-75%）已被提出作为远端气道口径的近似测量。支气管高反应性（BHR）是哮喘的一个特征，目的：探讨FEF25%-75%作为BHR预测指标在变应性哮喘和鼻炎患者中的可能作用。结果：1秒用力呼气量与FEF25%-75%之间的差值大于20或这些变量之间的比值大于1.24可区分对乙酰甲胆碱轻度反应无反应的患者与对乙酰甲胆碱中度至重度反应的患者，具有高灵敏度结论：FEF25%-75%在预测过敏性气道疾病患者BHR中可能具有重要作用。
Background: The small airways may play an important role in the clinical manifestations of asthma. Forced expiratory flow between 25% and 75% (FEF25%-75%) has been proposed as an approximate measure of the caliber of distal airways. Bronchial hyperreactivity (BHR) is a feature of asthma.Objective: To evaluate the possible role of FEF25%-75% as a predictor of BHR in allergic patients with asthma and rhinitis.Methods: A total of 726 patients (mean +/- SD age, 24.7 +/- 6.3 years) were evaluated. Spirometry and methacholine bronchial challenge were evaluated in all the participants.Results: A difference between forced expiratory volume in 1 second and FEF25%-75% greater than 20 or a ratio between these variables greater than 1.24 discriminates between patients with no response to a mild response to methacholine vs patients with a moderate-to-severe response with high sensitivity (P < .001).Conclusion: This study highlights the possible role of FEF25%-75% in predicting BHR in allergic individuals with airway disorders.