Erythrocyte glutathione levels as long-term predictor of transition to psychosis.
Erythrocyte glutathione levels as long-term predictor of transition to psychosis.
复制标题
DOI：
10.1038/tp.2017.30
复制
发表时间：
2017-03-21
影响因子：
6.8
通讯作者：
Amminger GP
中科院分区：
文献类型：
--
作者：
Lavoie S;Berger M;Schlögelhofer M;Schäfer MR;Rice S;Kim SW;Hesse J;McGorry PD;Smesny S;Amminger GP
很大一部分被认为有精神病高风险的人实际上永远不会发展成这种疾病。在这些情况下，药物干预可能是不必要的，实际上，根据治疗策略的侵入性，药物干预可能是有害的。这凸显了对生物标记物的需求，这些生物标记物能够更好地可靠地区分随后会转变为精神病的高危个体和不会转变为精神病的个体。在精神分裂症和首发精神病患者中观察到低谷胱甘肽（GSH）水平。本研究的目的是确定红细胞谷胱甘肽水平的预测价值的过渡到精神病的个体在发展疾病的风险。在36个高危个体中测量了红细胞GSH水平，其中15人在7年随访中转变为精神病。单因素Cox回归分析显示，在7年时间点向精神病的转变与基线时低GSH水平显著相关。接收工作特征曲线下面积为0.819，表明谷胱甘肽可作为预后的良好预测因子。虽然这些结果需要重复，但可能需要将“低红细胞GSH”标准添加到用于识别精神病风险个体的标准集中。
A high proportion of individuals deemed at elevated risk for psychosis will actually never progress to develop the illness. Pharmaceutical intervention may not be necessary in these cases, and may in fact be damaging depending on the invasiveness of the treatment strategy. This highlights the need for biomarkers that are better able to reliably differentiate between at-risk individuals who will subsequently transition to psychosis and those who will not. Low glutathione (GSH) levels have been observed in schizophrenia and in patients with first-episode psychosis. The aim of this study was to determine the predictive value of erythrocyte GSH levels on the transition to psychosis in individuals at risk of developing the illness. Erythrocyte GSH levels were measured in 36 at-risk individuals, 15 of whom had transitioned to psychosis at the 7-year follow-up. Univariate Cox regression analysis showed that transition to psychosis at the 7-year time point was significantly associated with low GSH levels at baseline. The area under the receiving operating characteristic curve was 0.819, indicating that GSH can be considered a good predictor of outcome. Although these results need to be replicated, adding the criterion ‘low erythrocyte GSH' to the set of criteria used to identify individuals at risk of psychosis may be indicated.