High prevalence of methicillin-resistant Staphylococcus aureus clone ST80-IV in hospital and community settings in Algiers
High prevalence of methicillin-resistant Staphylococcus aureus clone ST80-IV in hospital and community settings in Algiers
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DOI：
10.1111/j.1469-0691.2010.03273.x
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发表时间：
2011-04-01
影响因子：
14.2
通讯作者：
Etienne, J.
中科院分区：
文献类型：
--
作者：
Antri, K.;Rouzic, N.;Etienne, J.
USA300是美国流行的社区获得性耐甲氧西林金黄色葡萄球菌（C-MRSA）克隆，而欧洲C-MRSA克隆ST 80-IV主要在欧洲散发。欧洲克隆ST 80-IV在阿尔及利亚的流行情况记录不多。我们前瞻性地研究了S.在阿尔及尔的Mustapha Bacha医院进行了20个月的研究。S.在另外的6个月期间研究金黄色葡萄球菌鼻定殖。欧洲克隆ST80-IV造成了超过三分之一的社区感染（35.7%）和医院感染（35.8%）。从住院患者中分离的Panton-Valentine杀白细胞素（PVL）阳性MRSA对多种抗生素耐药，其中44.9%的病例对氟喹诺酮类抗生素耐药。PVL阳性MRSA鼻携带率在皮肤科患者和工作人员中较高（分别为8.7%和18.5%），但在门诊患者中较低（2.7%）。欧洲PVL阳性C-MRSA克隆ST 80-IV在阿尔及尔医院和社区环境中广泛存在。
P>USA300 is an epidemic community-acquired methicillin-resistant Staphylococcus aureus (C-MRSA) clone in the USA, whereas the European C-MRSA clone ST80-IV has mainly a sporadic diffusion in Europe. The prevalence of European clone ST80-IV in Algeria is poorly documented. We prospectively studied S. aureus infections at Mustapha Bacha hospital in Algiers over a 20-month period. S. aureus nasal colonization was studied during a further 6-month period. The European clone ST80-IV was responsible for more than one-third of both community infections (35.7%) and hospital infections (35.8%). Panton-Valentine leukocidin (PVL)-positive MRSA isolated from hospital inpatients were resistant to multiple antibiotics, including fluoroquinolones in 44.9% of cases. The PVL-positive MRSA nasal carriage rate was high among patients and staff in the dermatology unit (8.7% and 18.5%, respectively), but low (2.7%) among patients attending the outpatient clinic. The European PVL-positive C-MRSA clone ST80-IV is widespread in the Algiers hospital and community settings.