Suppression of peritoneal macrophage phagocytosis of Candida albicans by opioids.
Suppression of peritoneal macrophage phagocytosis of Candida albicans by opioids.
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发表时间：
1993-11
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通讯作者：
I. Szabo;Mikhail Rojavin;Jeanine L. Bussiere;Toby K. Eisenstein;Martin W. Adler;Thomas J. Rogers
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作者：
I. Szabo;Mikhail Rojavin;Jeanine L. Bussiere;Toby K. Eisenstein;Martin W. Adler;Thomas J. Rogers
已经发现受体选择性阿片激动剂抑制巨噬细胞摄取调理的绵羊红细胞的能力。为了进一步表征阿片类药物的免疫调节活性，进行了实验以检查阿片类药物处理的小鼠腹腔巨噬细胞对白色念珠菌的摄取。发现用吗啡和选择性μ，即，DAMGO，delta，即，DPDPE和κ，即，反式-3，4-二氯-N-甲基-N-[2-（1-吡咯烷基）环己基]苯-乙酰胺甲磺酸盐受体激动剂导致吞噬细胞百分比和摄入酵母菌平均数的浓度依赖性抑制。对μ具有选择性的拮抗剂，即，H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH 2，δ，即，纳曲吲哚和κ，即，norbinaltorphimine，阿片受体完全阻断各自的受体选择性激动剂诱导的抑制。这些结果表明，μ，δ和κ阿片受体可以调节巨噬细胞的功能。
Receptor-selective opioid agonists have been found to suppress the capacity of macrophages to ingest opsonized sheep erythrocytes. In an effort to characterize the immunomodulatory activity of opioids further, experiments were done to examine the uptake of Candida albicans by opioid-treated murine peritoneal macrophages. It was found that treatment with morphine and selective mu, i.e., DAMGO, delta, i.e., DPDPE, and kappa, i.e., trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl) cyclohexyl]benzene-acetamide methanesulfonate, receptor agonists resulted a concentration-dependent suppression of both the percentage of phagocytic cells and the average number of ingested yeasts. Antagonists selective for mu, i.e., H-D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2, delta, i.e., naltrindole, and kappa, i.e., norbinaltorphimine, opioid receptors completely blocked the respective receptor-selective agonist-induced suppression. These results suggest that the mu, delta and kappa opioid receptors can modulate macrophage function.