A perspective on narcolepsy.
A perspective on narcolepsy.
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对发作性睡病的看法。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
M. Mamelak
中科院分区：
文献类型：
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作者：
M. Mamelak
对3例发作性睡病患者尸检脑组织进行神经化学分析。显著的发现是去甲肾上腺素能和多巴胺能神经元活动增加，多巴胺能神经元活动减少，并且在3个大脑中的2个中，额叶皮层和杏仁核中的α-1-去甲肾上腺素能受体数量减少。在此基础上建立了一个嗜眠发作的病理生理学模型。发作性睡病的神经生物学与抑郁症进行了比较。MHC-II类基因产物在发作性睡病的发生中的作用进行了讨论。一些治疗的影响如下。
Neurochemical analyses were performed on brains obtained at post mortem from 3 patients with narcolepsy. The salient findings were an increase in noradrenergic and serotonergic neuronal activity, a decrease in dopaminergic neuronal activity, and, in 2 of the 3 brains, a decrease in the number of alpha-1-noradrenergic receptors in the frontal cortex and amygdala. A pathophysiological model for narcolepsy is developed on the basis of these findings. The neurobiology of narcolepsy is compared with that of depression. The role of MHC--class II gene products in the genesis of narcolepsy is discussed. Some treatment implications follow.