The Drosophila mutation turnip has pleiotropic behavioral effects and does not specifically affect learning.
The Drosophila mutation turnip has pleiotropic behavioral effects and does not specifically affect learning.
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果蝇突变萝卜具有多效性行为效应，并且不会具体影响学习。
DOI：
10.1101/lm.3.5.425
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Tully,T
中科院分区：
文献类型：
--
作者：
Mihalek,RM;Jones,CJ;Tully,T
果蝇突变萝卜（tur）在嗅觉学习任务中表现不佳，并且蛋白激酶C （PKC）活性降低，因此被分离出来。PKC在多种生物体的神经系统中被发现，在学习和记忆相关过程中似乎起着重要作用。不幸的是，以前的报告中记录的turn的学习缺陷缺乏所需的控制来评估突变体不良表现的起源。我们分析了这种突变对联想学习和非联想学习以及PKC活性的影响。此外，还评估了突变对果蝇任务相关感觉运动能力的影响。虽然我们能够复制以前用turr获得的行为和生化结果，但我们发现turr突变也会影响对电击的反应，并导致苍蝇运动能力的急剧下降。因为运动是学习分析的一个重要组成部分，这个结果使得不可能得出转弯特别影响学习的结论，并证明了在条件反射实验中感觉运动控制的关键重要性。
The Drosophila mutant turnip (tur) was isolated on the basis of its poor performance in an olfactory learning task, and also has a reduction in protein kinase C (PKC) activity. PKC has been found in the nervous systems of a wide range of organisms and appears to have an important role in learning and memory-related processes. Unfortunately, previous reports documenting the learning defect of tur lacked the controls required to assess the origins of the poor performance of the mutant. We have analyzed the effects of the tur mutation on both associative and nonassociative learning as well as on PKC activity. Additionally, the effects of the mutation on the task-relevant sensorimotor abilities of the flies were assessed. Although we were able to replicate previous behavioral and biochemical results obtained with tur, we discovered that the tur mutation also affected response to electric shock and caused a drastic reduction in the locomotor ability of the flies. Because locomotion is an essential component of the learning assays, this result makes it impossible to conclude that tur specifically affects learning and demonstrates the crucial importance of sensorimotor controls in conditioning experiments.