High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients
High uric acid and low superoxide dismutase as possible predictors of all-cause and cardiovascular mortality in hemodialysis patients
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DOI：
10.1007/s11255-012-0233-x
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发表时间：
2013-08-01
影响因子：
2
通讯作者：
Stojanov, Marina
中科院分区：
文献类型：
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作者：
Antunovic, Tanja;Stefanovic, Aleksandra;Stojanov, Marina
我们研究了血尿酸（sUA）和超氧化物歧化酶（SOD）作为血液透析（HD）患者死亡率预测因素的作用，SOD、丁酰胆碱酯酶和丙二醛采用比色法测定，其他参数采用标准程序测定。采用双抗体夹心ELISA法检测超敏C反应蛋白（hsCRP）。（112.1 +/-A13.82 μ mol/L）显著低于死亡组存活者SOD活性（31.8 ± A6.61kU/L）高于死亡者（20.2 ± A3.03，p < 0.05）。Kaplan-Meier生存曲线显示基础sUA浓度最高的三分位数（127.11 μ mol/L，p < 0.001）和SOD浓度最低的三分位数（23.83 kU/L，p < 0.05）的死亡风险最大，提示高sUA和低SOD可能预测HD患者的全因死亡率和心血管死亡率。
We investigated the role of serum uric acid (sUA) and superoxide dismutase (SOD) as predictive factors for mortality in hemodialysis (HD) patients.SOD, butyrylcholinesterase, and malondialdehyde were estimated spectrophotometrically and the other parameters by standard procedures. High-sensitive C-reactive protein was assayed by a sandwich ELISA method.sUA among survivors (112.1 +/- A 13.82 mu mol/L) was significantly lower than in deceased (160.8 +/- A 16.81 mu mol/L, p < 0.001), while SOD was higher in survivors (31.8 +/- A 6.61 kU/L) than among deceased (20.2 +/- A 3.03, p < 0.05). Kaplan-Meier survival curves showed the greatest mortality risk in the highest tertile of basal sUA concentration (a parts per thousand yen127.11 mu mol/L, p < 0.001), and for SOD in the lowest tertile (a parts per thousand currency sign23.83 kU/L, p < 0.05).Our results suggest that high sUA and low SOD may predict all-cause and cardiovascular mortality in HD patients.