Barium responsiveness of the rat aorta and femoral artery during pregnancy.
Barium responsiveness of the rat aorta and femoral artery during pregnancy.
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妊娠期间大鼠主动脉和股动脉的钡反应。
DOI：
10.1016/0024-3205(82)90648-8
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发表时间：
1982
期刊：
影响因子：
6.1
通讯作者：
J. Hart
中科院分区：
文献类型：
--
作者：
J. Hart
本文观察了未孕和孕鼠离体主动脉条和股动脉的钡反应。钡引起浓度相关的增加，从怀孕和非怀孕大鼠的血管张力。未孕和孕3周大鼠股动脉的浓度-反应曲线无差异;但孕1、2和3周大鼠胸主动脉的收缩力和浓度-反应线斜率均显著低于未孕大鼠胸主动脉。此外，钡引起的节律性收缩，在两个股动脉和腹主动脉的3周妊娠大鼠比非妊娠大鼠的血管更频繁地发展。在无钙Krebs中，妊娠3周大鼠的子宫内膜未出现节律性收缩。由于钡对各种肌肉的电和机械活动的影响已被假定为类似于和/或依赖于钙，这些结果可能表明，在怀孕期间发生的血管平滑肌钙敏感性的变化。这些变化可能有助于血液流动重新分配和其他心血管适应怀孕。
The barium responses of isolated aortic strips and femoral arteries from non-pregnant and pregnant rats were investigated. Barium caused concentration-related increases in tension of vessels from both pregnant and non-pregnant rats. The concentration-response curves of femoral arteries from non-pregnant and 3 week pregnant rats were not different; however contractility and slopes of concentration-response lines for thracic aortas from 1, 2 and 3 week pregnant rats were significantly less than those of aortas from non-pregnant rats. In addition, barium caused rhythmic contractions to develop in both femoral arteries and aortas of 3 week pregnant rats more frequently than vessels from non-pregnant rats. Rhythmic contractions did not develop in aortas from 3 week pregnant rats rats in calcium-free Krebs. Since the effects of barium on the electrical and mechanical activity of various muscles have been postulated to be similar to and/or dependent on calcium, these results may indicate that changes in calcium sensitivity of vascular smooth muscle occur during pregnancy. Such changes may contribute to the blood flow redistribution and other cardiovascular adaptations of pregnancy.