Neural regulation of acetylcholine sensitivity in embryonic sympathetic neurons.
Neural regulation of acetylcholine sensitivity in embryonic sympathetic neurons.
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胚胎交感神经元乙酰胆碱敏感性的神经调节。
DOI：
10.1073/pnas.85.8.2825
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发表时间：
1988
影响因子：
11.1
通讯作者：
Role,LW
中科院分区：
文献类型：
--
作者：
Role,LW
递质敏感性的发展是突触分化的重要组成部分。尽管大量的信息的外观乙酰胆碱（AcCho）的敏感性在神经肌肉接头，发病和调节突触发生的这一关键方面还没有以前检查神经元之间的突触形成。为了确定是否有突触前输入在神经元间突触的乙酰胆碱敏感性的诱导中的作用，乙酰胆碱诱导的电流在胚胎交感神经元突触形成之前和之后在体外测量。突触后神经元的总AcCho敏感性增加近10倍神经支配后。神经支配的影响是模仿介质条件的节前神经元，这表明突触前神经元调节突触后乙酰胆碱的敏感性释放的可溶性因子。这些观察提供证据表明，突触前输入调节神经元的敏感性，以确定突触递质。
The development of transmitter sensitivity is an important component of synaptic differentiation. Despite a wealth of information about the appearance of acetylcholine (AcCho) sensitivity at the neuromuscular junction, the onset and regulation of this critical aspect of synaptogenesis has not previously been examined for synapse formation between neurons. To determine whether there is a role of presynaptic input in the induction of AcCho sensitivity at interneuronal synapses, AcCho-induced currents were measured in embryonic sympathetic neurons before and after synapse formation in vitro. The total AcCho sensitivity of postsynaptic neurons was increased nearly 10-fold after innervation. The effects of innervation are mimicked by medium conditioned by preganglionic neurons, suggesting that presynaptic neurons regulate postsynaptic AcCho sensitivity by release of a soluble factor. These observations provide evidence that presynaptic input regulates neuronal sensitivity to an identified synaptic transmitter.