INTERPOSITIONAL POLYTETRAFLUOROETHYLENE GRAFTS - CONJUNCTIVAL BIOCOMPATIBILITY
INTERPOSITIONAL POLYTETRAFLUOROETHYLENE GRAFTS - CONJUNCTIVAL BIOCOMPATIBILITY
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DOI：
10.1097/00002341-199112000-00008
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发表时间：
1991-12-01
影响因子：
2
通讯作者：
RODRIGUES, MM
中科院分区：
文献类型：
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作者：
KARESH, JW;FABREGA, MA;RODRIGUES, MM
聚四氟乙烯（PTFE）是一种合成、编织、不可吸收、无抗原性的聚四氟乙烯相关材料，已被证明可用于矫正眼睑退缩，并在初次和二次手术中用作植入物包封材料，以矫正眼球缺失。如果没有完全覆盖一层结膜上皮，植入的PTFE将挤出。体外研究表明，用胶原蛋白、纤连蛋白、明胶或层粘连蛋白涂覆PTFE可促进上皮细胞和成纤维细胞在PTFE上迁移和粘附。体内研究表明，1型胶原涂层通过促进结膜上皮附着和生长在暴露的PTFE上，在防止移植物挤出方面最为成功。需要进一步研究来确定最佳PTFE涂层和孔径，以确保未覆盖的植入PTFE移植物的一致保留。
Polytetrafluoroethylene (PTFE) is a synthetic, woven, nonabsorbable, nonantigenic, Teflon-related material that has been shown to be useful in correcting eyelid retraction and as an implant enveloping material in primary and secondary surgery to correct anophthalmos. Implanted PTFE will extrude if not entirely covered with a layer of conjunctival epithelium. In vitro studies demonstrated that coating PTFE with collagen, fibronectin, gelatin, or laminin promotes epithelial cell and fibroblast migration over and adherence to PTFE. In vivo studies showed that a coating of type 1 collagen is most successful in preventing graft extrusion by promoting conjunctival epithelial attachment and growth over exposed PTFE. Further studies are needed to determine the optimum PTFE coating and pore size needed to ensure the consistent retention of uncovered implanted PTFE grafts.