Association between polymorphisms in the fatty acid desaturase gene cluster and the plasma triacylglycerol response to an n-3 PUFA supplementation.
Association between polymorphisms in the fatty acid desaturase gene cluster and the plasma triacylglycerol response to an n-3 PUFA supplementation.
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作者：
Cormier H;Rudkowska I;Paradis AM;Thifault E;Garneau V;Lemieux S;Couture P;Vohl MC
据报道，二十碳五烯酸和二十二碳六烯酸对心血管疾病风险因素具有多种有益作用。然而，在不同的研究中观察到对ω-3（n-3）多不饱和脂肪酸（PUFA）补充的血浆脂质反应的大的个体间变异性。遗传变异可能影响血脂反应性。本研究的目的是检查与n-3 PUFA补充对血脂谱的影响，在脂肪酸去饱和酶（FADS）基因簇的单核苷酸多态性（SNP）的存在。来自魁北克市地区的总共208名受试者在六周期间补充了3 g/天的n-3 PUFA。在包括基因型、补充剂和基因型与补充剂相互作用的影响的统计模型中，SNP rs 174546与补充剂前和补充剂后的血浆甘油三酯（TG）水平显著相关（p = 0.02）。n-3补充剂对血浆TG水平有独立影响，并且没有观察到显著的基因型与补充剂的相互作用。总之，我们的数据支持FADS基因簇是血浆TG水平的主要决定因素的观点。SNP rs 174546可能是与血浆TG水平和FADS 1基因表达相关的重要SNP，独立于使用n-3 PUFA的营养干预。
Eicosapentaenoic and docosahexaenoic acids have been reported to have a variety of beneficial effects on cardiovascular disease risk factors. However, a large inter-individual variability in the plasma lipid response to an omega-3 (n-3) polyunsaturated fatty acid (PUFA) supplementation is observed in different studies. Genetic variations may influence plasma lipid responsiveness. The aim of the present study was to examine the effects of a supplementation with n-3 PUFA on the plasma lipid profile in relation to the presence of single-nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene cluster. A total of 208 subjects from Quebec City area were supplemented with 3 g/day of n-3 PUFA, during six weeks. In a statistical model including the effect of the genotype, the supplementation and the genotype by supplementation interaction, SNP rs174546 was significantly associated (p = 0.02) with plasma triglyceride (TG) levels, pre- and post-supplementation. The n-3 supplementation had an independent effect on plasma TG levels and no significant genotype by supplementation interaction effects were observed. In summary, our data support the notion that the FADS gene cluster is a major determinant of plasma TG levels. SNP rs174546 may be an important SNP associated with plasma TG levels and FADS1 gene expression independently of a nutritional intervention with n-3 PUFA.
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