HETEROSEXUAL COTRANSMISSION OF HEPATITIS-C VIRUS (HCV) AND HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)
HETEROSEXUAL COTRANSMISSION OF HEPATITIS-C VIRUS (HCV) AND HUMAN-IMMUNODEFICIENCY-VIRUS (HIV)
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DOI：
10.7326/0003-4819-115-10-764
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发表时间：
1991-11-15
影响因子：
39.2
通讯作者：
GOEDERT, JJ
中科院分区：
文献类型：
--
作者：
EYSTER, ME;ALTER, HJ;GOEDERT, JJ
目的：确定多次输血男性血友病患者的女性性伴侣中丙型肝炎病毒 (HCV) 抗体的患病率，并比较 HCV 和人类免疫缺陷病毒 (HIV) 的传播频率。研究设计：HCV 和 HIV 抗体的横断面测量。地点：十个血友病治疗中心。患者：231 名多次输血男性血友病患者的总共 234 名女性性伴侣。测量和主要结果：丙型肝炎病毒抗体的患病率HCV 阳性男性的女性性伴侣中，194 人中有 5 人（2.6%）有 HCV 抗体（抗 HCV）。 HIV 阳性男性的女性性伴侣中，196 名女性性伴侣中，有 25 名（12.8%）的艾滋病毒感染率。 HIV 阳性/HCV 阳性男性的 164 名女性性伴侣中有 5 名 (3%) 感染了 HCV，而 HIV 阴性/HCV 阳性男性的 30 名女性性伴侣则没有感染 HCV。 HIV 阳性/HCV 阳性男性的 164 名女性性伴侣中，有 21 名 (13%) 感染了 HIV，而 HIV 阳性/HCV 不确定男性的 32 名女性性伴侣中，有 4 名 (13%) 感染了 HIV。共同感染的男性传播两种病毒的可能性是偶然预期的五倍（P = 0.01）。当单一病毒传播给女性性伴侣时，HIV 比 HCV 更常见（164 例中的 18 例与 164 例中的 2 例相比，P = 0.001；比值比，8.5；95% Cl，2.2 至 33.1）。结论：血友病男性的女性性伴侣中 HCV 患病率高于献血者和其他低危人群，表明性传播水平较低。丙型肝炎病毒（HCV）的男性向女性性传播效率低于艾滋病毒（HIV）。当 HIV 也被传播时，HCV 传播给性伴侣的频率要高出五倍，这表明 HIV 可能是 HCV 性传播的辅助因素。
Objectives: To determine the prevalence of antibodies to hepatitis C virus (HCV) in female sexual partners of multitransfused men with hemophilia and to compare the frequency of transmission of HCV and human immunodeficiency virus (HIV).Study Design: Cross-sectional measurement of HCV and HIV antibodies.Setting: Ten hemophilia treatment centers.Patients: A total of 234 female sexual partners of 231 multitransfused men with hemophilia.Measurements and Main Results: The prevalence of antibodies to HCV (anti-HCV) among female sexual partners of HCV-Positive men was 5 of 194 (2.6%). Anti-HIV prevalence among female sexual partners of HIV-positive men was 25 of 196 (12.8%). Five (3%) of the 164 female sexual partners of HIV-positive/HCV-positive men were infected with HCV compared with none of the 30 female sexual partners of HIV-negative/HCV-positive men. Twenty-one (13%) of the 164 female sexual partners of HIV-positive/HCV-positive men were infected with HIV compared with 4 (13%) of 32 female sexual partners of HIV-positive/HCV-indeterminate men. The co-infected men were five times more likely to transmit both viruses than would be expected by chance (P = 0.01). When a single virus was transmitted to a female sexual partner, it was more often HIV than HCV (18 of 164 compared with 2 of 164, P = 0.001; odds ratio, 8.5; 95% Cl, 2.2 to 33.1).Conclusions: The higher prevalence of HCV in female sexual partners of men with hemophilia than in blood donor and other low-risk groups suggests that there is a low level of sexual transmission. Male to female sexual transmission of HCV is less efficient than that of HIV. The frequency of HCV transmission to sexual partners is five times higher when HIV is also transmitted, suggesting that HIV may be a cofactor for the sexual transmission of HCV.