Sex differences in predictors of outcome in selected physical acute low back therapy interventions for pain
Sex differences in predictors of outcome in selected physical acute low back therapy interventions for pain
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DOI：
10.2519/jospt.2006.2270
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发表时间：
2006-06-01
影响因子：
6.1
通讯作者：
Brennan, Gerard P.
中科院分区：
文献类型：
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作者：
George, Steven Z.;Fritz, Julie M.;Brennan, Gerard P.
研究设计：对3项随机试验的汇总数据进行二次分析。
目的：本研究调查了急性下腰痛对物理治疗干预反应的性别差异。
背景：文献中一直有关于实验性疼痛敏感性的性别差异的描述。然而，这些性别差异的临床后果尚未被广泛报道。
方法与测量：受试者（n = 165）是来自普通社区和军队社区门诊物理治疗诊所的3项物理治疗干预随机试验的参与者。受试者被随机分配接受脊柱推拿结合活动度练习、腰椎稳定练习或方向偏好练习。在4周时通过疼痛强度和疼痛相关残疾的自我报告来测量结果。通过独立t检验（基线数据）、2×3方差分析（4周时疼痛和疼痛相关残疾的减少情况）以及回归模型（结果的预测因素）来研究性别差异。
结果：在4周内，男性和女性在疼痛强度（原始平均差异，0.5；95%置信区间，-1.4到0.4）和疼痛相关残疾（原始平均差异，5.3；95%置信区间，-0.1到10.7）的减少方面相似。基线疼痛强度、症状持续时间和基线疼痛相关残疾对女性疼痛强度的变化有显著预测作用（r² = 26%，P<...（此处原文似乎不完整）
Study Design: Secondary analysis of pooled data from 3 randomized trials.Objective: This study investigated sex differences in response to physical therapy intervention for acute low back pain. Background: Sex differences in experimental pain sensitivity have been consistently described in the literature. However, clinical consequences of these sex differences have not been widely reported.Methods and Measures: Subjects (n = 165) were participants in 3 randomized trials of physical therapy interventions from outpatient physical therapy clinics in the general and military communities. Subjects were randomly assigned spinal manipulation with range-of-motion exercise, lumbar stabilization exercise, or directional-preference exercise. Outcomes were measured at 4 weeks through self-report of pain intensity and pain-related disability. Sex differences were investigated with independent t tests (baseline data), 2 x 3 analysis of variance (4-week reductions in pain and pain-related disability), and regression models (predictors of outcome).Results: Men and women had similar reductions of pain intensity (raw mean difference, 0.5; 95% Cl, -1.4 to 0.4) and pain-related disability (raw mean difference, 5.3; 95% Cl, -0.1 to 10.7) over 4 weeks. Baseline pain intensity, duration of symptoms, and baseline pain-related disability significantly predicted change in pain intensity for women (r(2) = 26%, P