The Role of MicroRNAS in Ankylosing Spondylitis.
The Role of MicroRNAS in Ankylosing Spondylitis.
复制标题
MicroRNAS 在强直性脊柱炎中的作用
DOI：
10.1097/md.0000000000003325
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发表时间：
2016-04
期刊：
影响因子：
1.6
通讯作者：
Wu WKK
中科院分区：
文献类型：
--
作者：
Li Z;Wong SH;Shen J;Chan MTV;Wu WKK
强直性脊柱炎（Ankylosing Spondylitis，AS）是一种常见的遗传杂合子型炎症性风湿性疾病，以髋关节、骶髂关节和脊柱的新骨形成、强直和炎症为特征。到现在为止，目前还没有AS的早期诊断方法，AS患者的有效治疗方法在很大程度上还没有确定。我们使用医学主题词（MeSH）或标题/摘要词检索PubMed（MEDLINE）数据库中的文献（“microRNA”和“强直性脊柱炎”）从开始到2015年11月，miRNAs及其靶基因的遗传多态性可能会改变AS发生的风险，而某些miRNAs表现出相关性。在AS患者的循环免疫细胞中，Let-7i和miR-124上调，而miR-130 a下调。这些失调的miRNA可以调节关键的免疫细胞功能，如细胞因子反应和T细胞存活。然而，临床利用miRNAs治疗AS患者需要进一步的支持，从未来的翻译研究。
AbstractAnkylosing spondylitis (AS) is a common and genetically heterozygous inflammatory rheumatic disease characterized by new bone formation, ankylosis and inflammation of hip, sacroiliac joints and spine. Until now, there is no method for early diagnosis of AS and the effective treatment available for AS patients remain largely undefined.We searched articles indexed in PubMed (MEDLINE) database using Medical Subject Heading (MeSH) or Title/Abstract words (“microRNA” and “ankylosing spondylitis”) from inception up to November 2015.Genetic polymorphisms of miRNAs and their targets might alter the risk of AS development whereas certain miRNAs exhibit correlation with inflammatory index.Let-7i and miR-124 were upregulated whereas miR-130a was downregulated in circulating immune cells of AS patients. These deregulated miRNAs could modulate key immune cell functions, such as cytokine response and T-cell survival.miRNA deregulation is key to AS pathogenesis. However, clinical utilization of miRNAs for management of AS patients requires further support from future translational studies.