Benzoylurea oligomers:: Synthetic foldamers that mimic extended α helices
Benzoylurea oligomers:: Synthetic foldamers that mimic extended α helices
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DOI：
10.1002/anie.200701869
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发表时间：
2007-01-01
影响因子：
16.6
通讯作者：
Hamilton, Andrew D.
中科院分区：
文献类型：
--
作者：
Rodriguez, Johanna M.;Hamilton, Andrew D.
本文介绍了一个研究，探讨了一种迭代合成苯甲酰脲低聚物，这是开发通过使用单体单元，仲酰胺和异氰酸酯，衍生自氨基苯甲酸。它观察到的螺旋构象的基础上的α-螺旋模仿的结果。它讨论了研究中使用的方法，如核磁共振（NMR）光谱，并得出结论，苯甲酰脲衍生物可以作为螺旋模拟物破坏B细胞淋巴瘤的相互作用。
The article presents a research that examines an iterative synthesis which was developed for the benzoylurea oligomers by using monomer units, secondary amide and isocyanate, derived from aminobenzoic acid. It observes the findings of helical conformation based on ɑ-helix mimicry. It discusses methodologies used in the study such as nuclear magnetic resonance (NMR) spectroscopy and concludes that benzoylurea derivatives can act as helix mimetics in disrupting B-cell lymphoma interactions.