Regulation of cellular interferon production: enhancement by antimetabolites.
Regulation of cellular interferon production: enhancement by antimetabolites.
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细胞干扰素产生的调节：抗代谢物的增强。
DOI：
10.1073/pnas.67.1.464
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发表时间：
1970
影响因子：
11.1
通讯作者：
M. Ho
中科院分区：
文献类型：
--
作者：
Y. Tan;J. Armstrong;Y. Ke;M. Ho
在蛋白质抑制浓度下，当给予暴露于紫外线照射的纽卡斯尔病毒或多聚肌苷酸和多聚胞苷酸复合物（聚I.聚C）的兔肾细胞培养物时，可增强干扰素的产生。如果除了放线菌酮外，细胞还用放线菌素D处理，则增强作用更大。基于这些发现，假设这两种物质刺激干扰素产生的机制主要是产生一种通常抑制干扰素产生的对照蛋白。
Cycloheximide, at a protein-inhibitory concentration, when given to rabbit kidney cell cultures that had been exposed either to UV-irradiated Newcastle Disease virus or to a complex of polyinosinic and polycytidylic acids (poly I.poly C), enhanced the production of interferon. The enhancement was greater if, in addition to cycloheximide, the cells were also treated with actinomycin D. On the basis of these findings, a mechanism, consisting primarily of the production of a control protein which normally checks interferon production, is postulated for interferons stimulated by these two substances.