The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark Part I
The influence of folic acid supplement on the outcome of pregnancies in the county of Funen in Denmark Part I
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DOI：
10.1016/s0301-2115(99)00084-6
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发表时间：
1999-12-01
影响因子：
2.6
通讯作者：
Foged, N
中科院分区：
文献类型：
--
作者：
Rolschau, J;Kristoffersen, K;Foged, N
目的：确定孕前或孕早期补充叶酸是否对出生体重、早产、低出生体重和小于胎龄儿的发生率有任何影响。此外，目的是阐明两种不同剂量叶酸（即2.5和1.0 mg）给药后结果是否不同。材质：居住在丹麦富嫩岛（人口500 000）的所有育龄妇女都在3年零3个月的时间内补充了叶酸。14 021名妇女进行了登记，她们生育了13 860名一胎和325名多胎子女。共有8184名妇女参加了这项双盲随机试验：2310名妇女在没有随机分配的情况下补充了叶酸，2721名妇女没有补充叶酸。在806例妊娠中没有关于叶酸使用的信息。流产（512例）被排除在外。结果与结论：补充叶酸1.0 mg与2.5 mg效果相同。在一个富裕的北方国家，在怀孕前或怀孕前半期补充叶酸的效果是，出生体重略有增加，早产、出生体重低和小于胎龄儿的发生率下降。在孕前接受叶酸的组中观察到最大的效果。(C)1999由Elsevier Science爱尔兰有限公司出版。保留所有权利。
Objective: To determine whether a supplement of folic acid given preconceptionally or early in pregnancy had any influence on, birth weight, incidence of preterm labour, low birth weight and small for gestational age. Furthermore, the aim was to elucidate, whether the outcome differed following the administration of two different dosages of folic acid, namely 2.5 and 1.0 mg. Material: All women in the childbearing age living on the island of Funen, Denmark (population 500 000) were offered a supplement of folic acid over a period of 3 years and 3 months. 14 021 women, who gave birth to 13 860 single-born and 325 multiborn children, were registered. A total of 8184 women took part in the double-blind randomized trial: 2310 had a supplement of folic acid without being randomized and 2721 women received no folic acid supplement. No information regarding the use of folic acid was available in 806 pregnancies. Abortions (512) were excluded. Results and conclusions: A supplement 1.0 mg folic acid had the same effect as 2.5 mg. The effects of supplementing the diet with folic acid given preconceptionally or in the first half of pregnancy in an affluent Northern country were a slight increase of birth weight and a decrease in the incidence of preterm labour, infants with low birth weight and small for gestational age. The greatest effect was seen in the groups receiving folic acid preconceptionally. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.