CHEMOSENSITIVITY OF RAT NASAL TRIGEMINAL RECEPTORS
CHEMOSENSITIVITY OF RAT NASAL TRIGEMINAL RECEPTORS
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DOI：
10.1016/0031-9384(82)90216-5
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发表时间：
1982-01-01
影响因子：
2.9
通讯作者：
MOULTON, DG
中科院分区：
文献类型：
--
作者：
SILVER, WL;MOULTON, DG
通过空气稀释嗅觉计传递的气味的电生理反应记录从支配鼻腔的三叉神经的筛窦分支。对9种化合物获得了保留值，其中庚醇（21 - 137 ppm）和丙酸（39 - 49）ppm的保留值始终最低。并非所有的气味剂，例如，苯乙醇引起的反应，在所有大鼠，即使在蒸汽饱和。大鼠全神经电生理反应幅度与Doty等人（1978）的工作中确定的对蒸汽饱和刺激的人类嗅觉丧失强度评级之间存在显著的相关性。该比率似乎是评估气味剂对人类三叉神经受体的刺激有效性的极好模型。三叉神经系统在气味的感知以及气味的生理效应，由于三叉神经刺激的可能作用进行了讨论。[测试的其它增味剂是乙酸戊酯、乙酸苄酯、丁醇、环己烷、芳樟醇和α-环己醇。松油醇。
Electrophysiological responses to odorants delivered via an air dilution olfactometer were recorded from the ethmoid branch of the trigeminal nerve innervating the nasal cavity. Thresholds were obtained for 9 compounds with those for heptanol (21-137 ppm) and propionic acid (39-49) ppm consistently being the lowest. Not all odorants, e.g., phenethyl alcohol, elicited responses in all rats even at vapor saturation. A striking degree of correlation was present between the rat whole-nerve electrophysiological response magnitudes and the human anosmic intensity ratings, established in the work of Doty et al. (1978), to vapor saturated stimuli. The rate seems to be an excellent model for assessing the stimulatory effectiveness of odorants on human trigeminal receptors. The possible role of the trigeminal system in the perception of odors as well as the physiological effects of odorants due to trigeminal stimulation are discussed. [Other odorants tested were amyl acetate, benzyl acetate, butanol, cyclohexane, linalool and .alpha.-terpineol.].