Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor
Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor
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DOI：
10.1056/nejm199810223391701
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发表时间：
1998-10-22
影响因子：
158.5
通讯作者：
Takaku, F
中科院分区：
文献类型：
--
作者：
Sasazuki, T;Juji, T;Takaku, F
背景在无关供者造血干细胞移植中，对HLA相容性的要求以及HLA I类和II类等位基因配型的相对重要性尚未建立。HLA-A、B和DR抗原的相应受体。结果多因素分析显示，HLA-A等位基因不合和HLA-C等位基因不合是严重急性移植物抗宿主病（GVHD）的独立危险因素（HLA-A，P=0.006; HLA-C，P=0.001）。HLA-A等位基因的错配是死亡的独立危险因素，而HLA-C等位基因的错配不是死亡的独立危险因素。
Background The requirements with respect to HLA compatibility and the relative importance of matching for individual class I and class II HLA alleles in the transplantation of hematopoietic stem cells from unrelated donors have not yet been established.Methods We performed retrospective DNA typing of alleles at 11 polymorphic loci of HLA genes in 440 recipients of hematopoietic stem cells from unrelated donors who were serologically identical with their respective recipients for HLA-A, B, and DR antigens. Of these recipients, 80 percent had leukemia; the rest had lymphoma, marrow failure, or a congenital disorder.Results Multivariate analysis showed that incompatibility for HLA-A alleles and incompatibility for HLA-C alleles were independent risk factors for severe acute graft-versus-host disease (GVHD) (HLA-A, P=0.006; HLA-C, P=0.001). Mismatching of HLA-A, but not of HLA-C, alleles was an independent risk factor for death (P