Secretory immunity following mutans streptococcal infection or immunization.
Secretory immunity following mutans streptococcal infection or immunization.
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变形链球菌感染或免疫后的分泌免疫。
DOI：
10.1007/978-3-540-73900-5_6
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发表时间：
2008
影响因子：
--
通讯作者：
Mattos-Graner,RO
中科院分区：
文献类型：
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作者：
Smith,DJ;Mattos-Graner,RO
对变形链球菌的唾液IgA抗体反应可以在儿童早期观察到，有时甚至在口腔生物膜永久定植之前就可以观察到。许多早期免疫反应针对的是被认为对口腔生物膜中变形链球菌的建立和出现至关重要的成分。最初的反应可能受到抗原剂量、免疫成熟度以及先锋共生菌群中以前遇到的类似抗原表位的影响。我们对这些调节的理解
Salivary IgA antibody responses to mutans streptococci can be observed in early childhood, sometimes even before permanent colonization of the oral biofilm occurs. Many of these early immune responses are directed to components thought to be essential for establishment and emergence of mutans streptococci in the oral biofilm. Initial responses are likely to be modulated by antigen dose, by immunological maturity, and by previous encounters with similar antigenic epitopes in the pioneer commensal flora. Our understanding of these modulating