Blood preoperative neutrophil-to-lymphocyte ratio is correlated with TNM stage in patients with papillary thyroid cancer.
Blood preoperative neutrophil-to-lymphocyte ratio is correlated with TNM stage in patients with papillary thyroid cancer.
复制标题
DOI：
10.6061/clinics/2016(06)04
复制
发表时间：
2016-07
期刊：
影响因子：
--
通讯作者：
Guo F
中科院分区：
文献类型：
--
作者：
Gong W;Yang S;Yang X;Guo F
通过评估术前嗜中性粒细胞/淋巴细胞比值与肿瘤淋巴结转移分期之间的关系，预测美国联合癌症委员会甲状腺乳头状癌患者的肿瘤淋巴结转移分期。我们回顾性研究了161例诊断为甲状腺乳头状癌的患者。根据术前常规血液检查的中性粒细胞绝对计数和淋巴细胞绝对计数计算中性粒细胞/淋巴细胞比值，中性粒细胞/淋巴细胞比值≥ 2.0的患者被归类为高NLR组，而中性粒细胞/淋巴细胞比值小于2.0的患者被归类为低中性粒细胞/淋巴细胞比值组。临床病理变量，这是分层的中性粒细胞与淋巴细胞的比例，进行了分析。进行多变量分析以确定影响中性粒细胞/淋巴细胞比值的因素。采用斯皮尔曼等级相关分析≥45岁患者中性粒细胞/淋巴细胞比值与TNM分期之间的相关性。两组各项血液指标血红蛋白、血小板及促甲状腺激素水平无显著性差异。淋巴结转移、多灶性和肿瘤大小在两组中表现出显著差异（分别为p=0.000、p=0.000和p=0.035）。相关性分析表明，淋巴结转移、肿瘤较大和多灶性患者的术前中性粒细胞/淋巴细胞比值较高（分别为r=0.341，p=0.000; r=0.271，p=0.000; r=0.182，p=0.010）。对于≥45岁的患者，高NLR组中晚期TNM分期的患者数量高于低中性粒细胞/淋巴细胞比值组（p=0.013）。线性回归分析显示，术前中性粒细胞/淋巴细胞比值与美国联合癌症委员会肿瘤淋巴结转移分期呈正相关（rho=0.403，p=0.000）。术前中性粒细胞/淋巴细胞比值与甲状腺乳头状癌的分期密切相关。术前中性粒细胞/淋巴细胞比值的增加有助于≥45岁的甲状腺乳头状癌患者的晚期肿瘤淋巴结转移阶段。
To predict the American Joint Cancer Committee tumor-node-metastasis stage in patients with papillary thyroid carcinoma by evaluating the relationship between the preoperative neutrophil-to-lymphocyte ratio and the tumor-node-metastasis stage. We retrospectively examined 161 patients with a diagnosis of papillary thyroid carcinoma. The Neutrophil-to-Lymphocyte Ratio was calculated according to the absolute neutrophil counts and absolute lymphocyte counts on routine blood tests obtained prior to surgery and patients with a Neutrophil-to-Lymphocyte Ratio of 2.0 or more were classified as the high NLR group, while those with a Neutrophil-to-Lymphocyte Ratio less than 2.0 were classified as the low Neutrophil-to-Lymphocyte Ratio group. Clinicopathological variables, which were stratified by the Neutrophil-to-Lymphocyte Ratio, were analyzed. A multivariate analysis was performed to determine factors that affect the Neutrophil-to-Lymphocyte Ratio. The association between the Neutrophil-to-Lymphocyte Ratio and the TNM stage in patients ≥45 years of age was analyzed using the Spearman rank correlation. Various blood indices, including hemoglobin, platelet and thyroid-stimulating hormone levels in the two groups showed no significant differences. Lymph node metastasis, multifocality and tumor size exhibited significant differences in the two groups (p=0.000, p=0.000 and p=0.035, respectively). Correlation analysis indicated that a higher preoperative Neutrophil-to-Lymphocyte Ratio was observed in patients with lymph node metastasis, larger tumor size and multifocality (r=0.341, p=0.000; r=0.271, p=0.000; and r=0.182, p=0.010, respectively). For patients ≥45 years of age, the number of patients with an advanced TNM stage in the high NLR group was higher than that in the low Neutrophil-to-Lymphocyte Ratio group (p=0.013). A linear regression analysis showed that the preoperative Neutrophil-to-Lymphocyte Ratio was positively correlated with the American Joint Cancer Committee tumor-node-metastasis stage (rho=0.403, p=0.000). The preoperative Neutrophil-to-Lymphocyte Ratio was closely related to the stage of papillary thyroid carcinoma. The increase in the preoperative Neutrophil-to-Lymphocyte Ratio contributed to the advanced tumor-node-metastasis stage of papillary thyroid carcinoma patients ≥45 years of age.