Elevated levels of peritumoral chondroitin sulfate are predictive of poor prognosis in patients treated by radical prostatectomy for early-stage prostate cancer.
Elevated levels of peritumoral chondroitin sulfate are predictive of poor prognosis in patients treated by radical prostatectomy for early-stage prostate cancer.
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瘤周硫酸软骨素水平升高预示着接受根治性前列腺切除术治疗早期前列腺癌的患者预后不良。
作者：
C. Ricciardelli;D. Quinn;W. Raymond;K. McCaul;P. Sutherland;P. Stricker;J. Grygiel;R. Sutherland;V. Marshall;W. Tilley;D. Horsfall
局限性前列腺癌的病程是高度可变的，并且通过积极的管理可能治愈的患者不容易通过当前的临床实践来确定。硫酸软骨素（CS）糖胺聚糖是一种候选生物标志物，因为前列腺癌瘤周基质中CS水平升高与前列腺特异性抗原（PSA）失败有关。免疫反应性CS使用存档的根治性直肠癌切除术组织的图像分析进行测量，这些组织来自157名男性，中位临床随访时间为47个月（范围，16-111个月）。考克斯多变量分析显示，CS水平、Gleason评分和术前血清PSA水平是PSA失败的独立预测因素。低CS水平的患者在根治性前列腺切除术后PSA失败率显著低于高CS水平的患者（Kaplan-Meier图; CS平均积分吸光度临界点OR = 7.0时，5年时PSA失败率为32%< 7.0 versus 50% for CS >，P = 0.0001）。在术前血清PSA水平< 10 ng/ml的患者亚组中，CS在回顾性区分最适合手术的患者方面特别有用（Kaplan-Meier图; CS平均积分吸光度临界点< 7.0 versus 47% for CS >OR = 7.0，P = 0.0001，5年时PSA失败率为14%）。我们的结论是CS水平的测量可以帮助预测患者术后的结果。此外，我们的数据表明，CS和PSA测量的组合可能会提高中间Gleason评分的患者的预后预测。
The disease course of localized prostate cancer is highly variable, and patients potentially curable by aggressive management are not readily identified by current clinical practice. Chondroitin sulfate (CS) glycosaminoglycan is a candidate biomarker as elevated levels of CS in peritumoral stroma of prostate cancer have been associated with prostate-specific antigen (PSA) failure. Immunoreactive CS was measured using image analysis of archived radical prostatectomy tissues, obtained from 157 men with a median of 47 months (range, 16-111 months) clinical follow-up. CS level, Gleason score, and preoperative serum PSA levels were independent predictors of PSA failure by Cox's multivariate analysis. Patients with low CS levels had significantly fewer PSA failures after radical prostatectomy than patients with high levels of CS (Kaplan-Meier plot; 32% PSA failures at 5 years for CS mean integrated absorbance cut point < 7.0 versus 50% for CS > or = 7.0, P = 0.0001). In the subgroup of patients with preoperative serum PSA levels < 10 ng/ml, CS was particularly useful in discriminating retrospectively those patients most suited for surgery (Kaplan-Meier plot; 14% PSA failures at 5 years for CS mean integrated absorbance cut point < 7.0 versus 47% for CS > or = 7.0, P = 0.0001). We conclude that measurements of CS level can assist in predicting patient outcome after surgery. Additionally, our data suggest that the combination of CS and PSA measurements may improve outcome prediction for patients with intermediate Gleason scores.
人结肠癌基质中硫酸软骨素蛋白多糖表达的改变。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Adany,R;Heimer,R;Caterson,B;Sorrell,JM;Iozzo,RV
通讯作者：
Iozzo,RV
评估根治性前列腺切除术后血清前列腺特异性抗原速度，以区分局部复发和远处转移。
影响因子：
2.1
作者：
Partin,AW;Pearson,JD;Landis,PK;Carter,HB;Pound,CR;Clemens,JQ;Epstein,JI;Walsh,PC
通讯作者：
Walsh,PC