Fluctuation of abundance and Lassa virus prevalence in Mastomys natalensis in Guinea, West Africa
Fluctuation of abundance and Lassa virus prevalence in Mastomys natalensis in Guinea, West Africa
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DOI：
10.1089/vbz.2006.0520
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发表时间：
2007-06-01
影响因子：
2.1
通讯作者：
Ter Meulen, Jan
中科院分区：
文献类型：
--
作者：
Fichet-Calvet, Elisabeth;Lecompte, Emilie;Ter Meulen, Jan
根据经验性监测数据，据报告，与雨季相比，在几内亚和其他西非国家，人拉沙热病例的发病率在旱季有所增加。要调查可能的联系与生态的啮齿动物水库的病毒，我们进行了为期2年的纵向调查Mastomys natalensis在该地区的高人类拉沙病毒（LASV）血清阳性在几内亚。在3个村庄进行了标准化的鼠笼诱捕，季节之间的诱捕努力相似，53.5%（601/1123）的动物被鉴定为M。natalensis使用形态和分子标准。M的平均诱捕成功率（TS）。natalensis始终高于室内比近端培养。在旱季，平均TS在房屋内增加2倍，在房屋外减少10倍（p < 0.0001），表明由于食物供应受限，啮齿动物在房屋内聚集。14.5%（80/553）的M.用逆转录-聚合酶链反应（RT-PCR;范围，5%-30%）检测到纳塔尔人的拉沙病毒阳性，并且在雨季捕获的啮齿动物中的病毒感染率比旱季高2 - 3倍（p < 0.05）。然而，在房屋内，LASV患病率随季节波动不显着。这些数据表明，在几内亚，LASV从啮齿动物传播给人类的风险在雨季和旱季都存在，这反映在全年LF病例的发生上。然而，在旱季，人类在房屋内遇到Mastomys及其排泄物的风险增加，可能导致人类拉沙热病例增加。
Based on empiric surveillance data, the incidence of human Lassa fever (LF) cases in Guinea and other West African countries has been reported to increase during the dry season compared to the rainy season. To investigate possible links with the ecology of the rodent reservoir of the virus, we conducted a 2-year longitudinal survey of Mastomys natalensis in a region of high human Lassa virus (LASV) seropositivity in Guinea. Standardized rodent trapping with similar trapping efforts between seasons was performed in three villages and 53.5% (601/1123) of the animals were identified as M. natalensis using morphometric and molecular criteria. Mean trapping success (TS) of M. natalensis was always higher inside houses than in proximal cultivations. In the dry season, mean TS increased 2-fold inside houses and decreased up to 10-fold outside (p < 0.0001), suggesting aggregation of rodents inside houses due to restricted food supply. 14.5% (80/553) of M. natalensis were tested positive for Lassa virus by reverse transcription-polymerase chain reaction (RT-PCR; range, 5%-30%) and prevalence of the virus was two to three times higher in rodents captured in the rainy season than in the dry season (p < 0.05). Inside houses, however, the LASV prevalence fluctuated nonsignificantly with season. These data suggest that in Guinea the risk of LASV transmission from rodents to humans is present both in the rainy and the dry season, reflected by the occurrence of LF cases throughout the year. In the dry season, however, the increased risk of humans encountering Mastomys and their excreta inside of houses may result in an increase of human Lassa fever cases.