SOME LONG-TERM EFFECTS OF SMOKING ON THE HEMOSTATIC SYSTEM - REPORT FROM THE CAERPHILLY AND SPEEDWELL COLLABORATIVE SURVEYS
SOME LONG-TERM EFFECTS OF SMOKING ON THE HEMOSTATIC SYSTEM - REPORT FROM THE CAERPHILLY AND SPEEDWELL COLLABORATIVE SURVEYS
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DOI：
10.1136/jcp.40.8.909
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发表时间：
1987-08-01
影响因子：
3.4
通讯作者：
ETHERINGTON, MD
中科院分区：
文献类型：
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作者：
YARNELL, JWG;SWEETNAM, PM;ETHERINGTON, MD
来自南威尔士和英格兰西部的两项社区研究的数据表明，吸烟对止血系统的影响在戒烟后仍然存在多年。在戒烟者中发现了几个变量之间的长期相关性，包括血浆纤维蛋白原和白色细胞计数，以及戒烟后的时间长度。当前吸烟者在白色细胞计数和两个血液学变量（细胞压积和平均细胞体积）方面的剂量反应关系明显。这些长期相关性可能反映了烟草烟雾中除尼古丁和一氧化碳外的其他物质的毒性，这些物质仅在短期内起作用。这些因素的鉴定可能会进一步加深我们对吸烟与动脉粥样硬化疾病相关机制的理解。
Data from two community studies on men from South Wales and the west of England suggest that the effects of smoking on the haemostatic system remain for many years after giving up. Long term correlations between several variables, including plasma fibrogen and white cell count, and the length of time after giving up were seen in ex-smokers. Dose response relations were apparent in current smokers in terms of the white cell count and two haematological variables, the packed and mean cell volumes. These long term correlations probably reflect the toxicity of other agents in tobacco smoke besides nicotine and carbon monoxide, which act only in the short term. Identification of these agents may further our understanding of the mechanisms by which cigarette smoking is associated with atherosclerotic disease.