Rational combination of two privileged chiral backbones: Highly efficient organocatalysts for asymmetric direct aldol reactions between aromatic aldehydes and acylic ketones
Rational combination of two privileged chiral backbones: Highly efficient organocatalysts for asymmetric direct aldol reactions between aromatic aldehydes and acylic ketones
复制标题
两种特有手性主链的合理组合：用于芳香醛和酰基酮之间不对称直接羟醛反应的高效有机催化剂
DOI：
10.1021/jo800910s
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发表时间：
2008-08-01
影响因子：
3.6
通讯作者：
Xiao, Wen-Jing
中科院分区：
文献类型：
--
作者：
Chen, Jia-Rong;An, Xiao-Lei;Xiao, Wen-Jing
A new class of organocatalysts has been designed by rational combination of proline with cinchona alkaloids. The chiral amine 3a, prepared from L-proline and cinchonidine, has been found to be an efficient catalyst for the direct aldol reactions of acetone or 2-butanone with a wide range of aldehydes (up to 98% ee). The cinchonidine backbone is essential to the reaction efficiency and enantioselectivity.
