The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organs.
The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organs.
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DOI：
10.1002/ijc.26031
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发表时间：
2011-06-01
影响因子：
6.4
通讯作者：
Fidler, Isaiah J.
中科院分区：
文献类型：
--
作者：
Langley, Robert R.;Fidler, Isaiah J.
事实上，某些肿瘤表现出转移到特定器官的偏好已经被认识了世纪。大量的临床数据和实验研究证实了Stephen佩吉特最初的“种子和土壤”假说，即肿瘤转移的器官偏好模式是转移性肿瘤细胞（“种子”）与其器官微环境（“土壤”）之间有利相互作用的产物。实际上，目前用于治疗人类癌症的许多一线治疗方案被设计为靶向癌细胞（例如化疗）并且还调节肿瘤微环境（例如抗血管生成疗法）。虽然某些类型的肿瘤能够在身体的几乎每个器官中形成转移，但最常见的转移靶器官是骨、脑、肝和肺。在这篇综述中，我们讨论了肿瘤间质相互作用如何影响这些器官的转移。
The fact that certain tumors exhibit a predilection for metastasis to specific organs has been recognized for well over a century now. An extensive body of clinical data and experimental research has confirmed Stephen Paget's original “seed and soil” hypothesis that proposed the organ-preference patterns of tumor metastasis are the product of favorable interactions between metastatic tumor cells (the “seed”) and their organ microenvironment (the “soil”). Indeed, many of first-line therapeutic regimens currently in use for the treatment of human cancer are designed to target cancer cells (such as chemotherapy) and also to modulate the tumor microenvironment (such as anti-angiogenic therapy). While some types of tumors are capable of forming metastases in virtually every organ in the body, the most frequent target organs of metastasis are bone, brain, liver, and the lung. In this review, we discuss how tumor-stromal interactions influence metastasis in each of these organs.
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DOI：
10.1038/nrc2442
发表时间：
2008-08
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
50.3
作者：
Crawford, Yongping;Kasman, Ian;Ferrara, Napoleone
通讯作者：
Ferrara, Napoleone
影响因子：
20.1
作者：
Eppihimer, MJ;Wolitzky, B;Granger, DN
通讯作者：
Granger, DN
影响因子：
15.9
作者：
Guise, TA;Yin, JJ;Mundy, GR
通讯作者：
Mundy, GR
影响因子：
158.5
作者：
Cunningham, D;Humblet, Y;Van Cutsem, E
通讯作者：
Van Cutsem, E