A genome scan for diabetic nephropathy in African Americans
A genome scan for diabetic nephropathy in African Americans
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DOI：
10.1111/j.1523-1755.2004.00915.x
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发表时间：
2004-10-01
影响因子：
19.6
通讯作者：
Freedman, BI
中科院分区：
文献类型：
--
作者：
Bowden, DW;Colicigno, CJ;Freedman, BI
背景资料。有大量证据表明基因对非裔美国人糖尿病肾病易感性有影响，但对易感基因的位置或身份知之甚少。DNA样本来自166个非裔美国人家庭(355人)的206对2型糖尿病(T2 DM)和终末期肾病(ESRD)/肾病同胞。用非参数连锁回归(NPLR)分析和有序子集分析(OSA)方法进行基因组扫描和数据分析。在最初的NPLR分析中，没有观察到优势比(LOD)分数的对数>；2.0。有4个座位的LOD评分大于或等于1.0，其中7p染色体上29 cM处的LOD=1.43最高。多位点互作的NPLR分析检测到6个座位(7p、12p、14q、16p、18q和21q)，LOD得分在1.15到1.63之间。NPLR分析评估表型相互作用显示有证据的多个位置(P
Background. There is substantial evidence for a genetic contribution to diabetic nephropathy susceptibility in the African American population, but little is known about location or identity of susceptibility genes.Methods. DNA samples were collected from 206 type 2 diabetes (T2DM) and end-stage renal disease (ESRD)/nephropathy-affected sib pairs from 166 African American families (355 affected individuals). A genome scan was performed and data analyzed using nonparametric linkage regression (NPLR) analysis and ordered subsets analysis (OSA) methods.Results. In initial NPLR analyses no logarithm of odds (LOD) scores >2.0 were observed. Four loci had LOD scores greater than or equal to1.0, with LOD=1.43 at 29 cM on chromosome 7p the highest. NPLR analyses of multilocus interactions detected 6 loci (7p, 12p, 14q, 16p, 18q, and 21q) with LOD scores 1.15 to 1.63. NPLR analyses evaluating phenotypic interactions revealed multiple locations with evidence (P