OLFACTORY TYPE G-PROTEIN α SUBUNIT IN STRIOSOME-MATRIX DOPAMINE SYSTEMS IN ADULT MICE
OLFACTORY TYPE G-PROTEIN α SUBUNIT IN STRIOSOME-MATRIX DOPAMINE SYSTEMS IN ADULT MICE
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DOI：
10.1016/j.neuroscience.2010.06.072
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发表时间：
2010-10-13
期刊：
影响因子：
3.3
通讯作者：
Goto, S.
中科院分区：
文献类型：
--
作者：
Sako, W.;Morigaki, R.;Goto, S.
越来越多的证据表明纹状体基质多巴胺系统与运动和行为脑功能和疾病密切相关。在这项研究中，我们使用免疫组织化学方法显示了成年小鼠纹状体区室中涉及多巴胺D1受体与腺苷酸环化酶偶联的嗅觉型G蛋白α亚基（G alpha olf）的差异表达，并观察到纹状体中G alpha olf标记的密度相对于基质区室而言更高。我们的研究结果表明，G alpha olf 可能是控制成年小鼠纹状体中纹状体和基质区室对多巴胺 D1 受体信号传导差异反应的关键分子之一。 (C) 2010 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
There is a growing body of evidence that striosome-matrix dopamine systems are tightly linked with motor and behavioral brain functions and disorders. In this study, we used an immunohistochemical method to show differential expression of the olfactory type G-protein alpha subunit (G alpha olf) that involves in the coupling of dopamine D1 receptor with adenylyl cyclase in the striatal compartments of adult mice, and observed heightened density of G alpha olf labeling in the striosomes relative to the matrix compartment. Our findings suggest that G alpha olf could be one of the key molecules for controlling differential responses of the striosome and matrix compartments to dopamine D1 receptor signaling in the striatum of adult mice. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.