Source of intrinsic innervation of canine ventricles: a functional study.
Source of intrinsic innervation of canine ventricles: a functional study.
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犬心室内在神经支配的来源：功能研究。
DOI：
10.1152/ajpheart.1987.252.3.h638
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Romero,AM
中科院分区：
文献类型：
--
作者：
Blomquist,TM;Priola,DV;Romero,AM
最近有人提出，心室的副交感神经支配是通过从心房中的神经节细胞发出的节后轴突，通过穿过房室（AV）沟到达心室。我们设计了一系列实验来验证这一假设。在21只体外循环犬的房室沟和心外膜周围5 mm处应用苯酚（89%）。在β受体阻滞后，评价了冠状动脉内乙酰胆碱（ACh; 1-5 μ g）和冠状动脉内尼古丁（NIC; 25-100 μ g）对心脏等容压的影响。在另一系列实验中，8只狗以同样的方式接触苯酚，并允许恢复7-10天。与单独应用生理盐水相比，在急性动物中，将苯酚应用于AV沟不影响心房和心室对NIC的反应。然而，在慢性动物中，预先用苯酚预处理7-10天使心室对NIC的反应减少70%，而心房反应保持不变。这些数据表明，内在的心脏神经（ICN）的犬心室主要由节后副交感神经轴突产生的室上神经节和跨越AV沟。
Recently it has been suggested that the parasympathetic innervation of the ventricles is by way of postganglionic axones that emanate from ganglion cells in the atria, reaching the ventricles by traversing the atrioventricular (AV) groove. We designed a series of experiments to test this hypothesis. Phenol (89%) was applied to the AV groove and surrounding 5 mm of epicardium in 21 dogs on cardiopulmonary bypass. The effects of intracoronary acetylcholine (ACh; 1-5 micrograms) and intracoronary nicotine (NIC; 25–100 micrograms) on cardiac isovolumic pressures were evaluated after beta-blockade. In another series of experiments, eight dogs were exposed to phenol in the same way and allowed to recover for 7–10 days. Atrial and ventricular responses to NIC were unaffected by phenol application to the AV groove in the acute animals when compared with application of saline alone. However, in the chronic animals, pretreatment with phenol 7–10 days previously reduced the ventricular responses to NIC by 70% while leaving the atrial responses intact. These data indicate that the intrinsic cardiac nerves (ICN) of the canine ventricles consist primarily of postganglionic parasympathetic axones which arise from supraventricular ganglia and cross the AV groove.