Heritability of age at natural menopause in the Framingham Heart Study
Heritability of age at natural menopause in the Framingham Heart Study
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DOI：
10.1210/jc.2005-0181
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发表时间：
2005-06-01
影响因子：
5.8
通讯作者：
Cupples, LA
中科院分区：
文献类型：
--
作者：
Murabito, JM;Yang, Q;Cupples, LA
背景：双胞胎登记和家族史研究提供了遗传因素导致更年期发生的证据，但基于人群的样本的遗传力估计是有限的。我们试图估计参与多代弗雷明汉心脏研究（一项基于社区的流行病学研究）的女性自然绝经年龄的遗传力。方法：来自 1296 个大家庭的总共 1500 名原始队列和 932 名后代队列妇女报告了自然绝经，定义为月经自然停止 1 年或更长时间。使用《遗传流行病学统计应用》中的家庭相关性计算母女、姐妹姐妹和阿姨侄女对的相关系数。使用序列寡基因连锁分析例程（SOLAR）计算机软件包中的方差分量方法估计遗传力。多变量模型中的协变量包括世代、吸烟数量、体重指数和胎次。结果：原始队列和后代女性的自然绝经平均年龄分别为 49.1 岁和 49.4 岁。母女、姐妹和姑姑侄女对的多变量调整相关系数分别为 0.21、0.22 和 0.12。自然绝经年龄的粗略遗传力和多变量调整遗传力估计值分别为 0.49 (0.37, 0.61) 和 0.52 (0.35, 0.69)。结论：我们的数据表明，绝经年龄的个体间变异至少有 50% 似乎可归因于遗传效应。
Background: Twin registries and family history studies provide evidence that genetic factors contribute to the onset of menopause, but heritability estimates in population-based samples are limited. We sought to estimate heritability of age at natural menopause in women participating in the multigenerational Framingham Heart Study, a community-based epidemiological study.Methods: A total of 1500 original cohort and 932 offspring cohort women from 1296 extended families reported a natural menopause defined as the natural cessation of menses for 1 yr or more. Correlation coefficients were calculated using family correlations in Statistical Applications for Genetic Epidemiology for mother-daughter, sister-sister, and aunt-niece pairs. Heritability was estimated using variance-components methods in the Sequential Oligogenic Linkage Analysis Routines ( SOLAR) computer package. Covariates in the multivariable models included generation, number of cigarettes smoked, body mass index, and parity.Results: The mean age at natural menopause was 49.1 and 49.4 yr in original cohort and offspring women, respectively. The multivariable-adjusted correlation coefficients for mother-daughter, sister-sister, and aunt-niece pairs were 0.21, 0.22, and 0.12, respectively. The crude and multivariable-adjusted heritability estimates for age at natural menopause were 0.49 (0.37, 0.61) and 0.52 (0.35, 0.69).Conclusions: Our data suggest that at least 50% of the interindividual variability in menopausal age appears to be attributable to genetic effects.