Morphometric studies on the development of human thyroid gland in early fetal life.
Morphometric studies on the development of human thyroid gland in early fetal life.
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胎儿早期人类甲状腺发育的形态测量研究。
DOI：
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发表时间：
1992
影响因子：
2
通讯作者：
W. Woźniak
中科院分区：
文献类型：
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作者：
J. Bocian;Malendowicz Lk;W. Woźniak
本文对30例正常胎儿甲状腺进行了组织学和形态计量学研究。它们的顶臀长（CRL）范围为57至190毫米，对应于10-20周的胎龄。甲状腺重量与CRL、足长和胎仔体重成比例增加。在57 mm的CRL胎儿甲状腺外周部观察到第一个含有PAS阳性胶体的滤泡。甲状腺表面切片每1 mm 2的卵泡数增加至85 mm CRL，此后在研究的胎龄结束时逐渐下降。甲状腺上皮、胶质和间质的体积（单位：mm 3）从85 mm开始与CRL成比例增加，而上皮细胞的高度没有变化。上皮/胶体比显著降低至165 mm CRL，此后保持不变。本研究结果提示，人胎甲状腺在孕17.5周时已接近结构成熟。
Histological and morphometric studies were performed on 30 thyroid glands obtained from normal human fetuses. Their crown-rump length (CRL) ranged from 57 to 190 mm, corresponding to the gestational age of 10-20 weeks. The weight of the thyroid gland increased proportionally in relation to CRL, foot length and fetus weight. The first follicles containing PAS-positive colloid were observed in the peripheral part of the thyroid gland of 57 mm CRL fetus. The number of follicles per 1 mm2 of thyroid surface section increased up to 85 mm CRL and thereafter gradually declined for the end of studied period of fetal life. The volumes (in mm3) of thyroid epithelium, colloid and stroma, beginning from 85 mm increased proportionally to the CRL while the height of epithelial cells did not change. The epithelium/colloid ratio decreased notably to 165 mm CRL and thereafter remained constant. Results of the present study suggest that the thyroid gland of human fetus approaches structural maturity in 17.5 week of gestation.