The use of contrasted transvaginal sonography in the diagnosis of gynecologic diseases - A preliminary study
The use of contrasted transvaginal sonography in the diagnosis of gynecologic diseases - A preliminary study
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DOI：
10.7863/jum.2005.24.9.1267
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发表时间：
2005-09-01
影响因子：
2.3
通讯作者：
Timmerman, D
中科院分区：
文献类型：
--
作者：
Testa, AC;Ferrandina, G;Timmerman, D
Objective.本研究的目的是评价一种新的造影剂专用超声技术，对比度调整成像（CnTI），在阴道内探头上实施，并使用第二代造影剂SonoVue（Brampton International BV，Amsterdam，the Netherlands），与标准超声检查相比，在不同的妇科疾病中的疗效。方法. 89例患者在4个不同的临床中心入组研究。该研究包括40例不确定的盆腔附件肿块，10例盆腔肿块提示妇科肿瘤复发，26例子宫病理特征，13例宫颈病变患者。结果SonoVue注射后应用CnTI技术显示的病灶内微血管与彩色多普勒检查中获得的图像明显不同。在40例盆腔肿块中，B超和彩色多普勒检查15例（37.5%）为良性，25例（62.5%）为恶性。超声造影显示11例（73%）病灶内无造影剂灌注，最终诊断均为良性。在4例（27%）有灌注的病例中，2例为恶性。相反，25例彩色多普勒检查阳性结果，因此预期显示造影剂组织填充形态学特征的出现，13例（52%）在最终诊断时为恶性。对于子宫病理学特征的评价，CnTI-SonoVue技术似乎并不上级B型和彩色多普勒检查;然而，对于宫颈癌的评价，CnTI-SonoVue技术在10例病例中的4例（40%）中显示了肿瘤病变边缘的更好定义。结论。在评价不确定的盆腔肿块时，CnTl技术提高了医生区分良性和恶性附件病变的能力。
Objective. The purpose of this study was to evaluate the efficacy of a new contrast-dedicated ultrasound technology, contrast-tuned imaging (CnTI), implemented on an endovaginal probe and using the second-generation contrast agent SonoVue (Bracco International BV, Amsterdam, the Netherlands), compared with the standard ultrasound examination in different gynecologic diseases. Methods. Eighty-nine patients were enrolled in the study in 4 different clinical centers. The study included 40 patients with uncertain pelvic adnexal masses, 10 patients with pelvic masses indicative of recurrences of gynecologic tumors, 26 patients with uterine pathologic features, and 13 patients with cervical lesions. Results. Application of CnTI technology after the SonoVue injection gave a picture of the intralesional microvascularization dramatically different from that obtained during color Doppler examination. Of the 40 pelvic masses, 15 (37.5 %) were considered benign and 25 (62.5 %) were considered malignant at B-mode and color Doppler examinations. Contrast-enhanced sonography showed no intralesional contrast perfusion in 11 (73 %) of 15 cases, and all these were benign at final diagnosis. Of the 4 (27 %) cases that had perfusion, 2 were malignant. Conversely, of the 25 cases with positive findings at color Doppler examination and therefore expected to show the appearance of contrast tissue-filling morphologic characteristics, 13 (52 %) were malignant at final diagnosis. For evaluation of uterine pathologic features, the CnTI-SonoVue technology did not appear to be superior to the B-mode and color Doppler examinations; however, for the evaluation of cervical cancer, CnTI-SonoVue technology revealed a better definition of the margins of the neoplastic lesions in 4 (40 %) of 10 cases. Condusions. In the evaluation of uncertain pelvic masses, the CnTl technology led to an improvement in the ability of the practitioner to differentiate benign from malignant adnexal lesions.