Pharmacokinetic Investigation of Commercially Available Edible Marijuana Products in Humans: Potential Influence of Body Composition and Influence on Glucose Control.
Pharmacokinetic Investigation of Commercially Available Edible Marijuana Products in Humans: Potential Influence of Body Composition and Influence on Glucose Control.
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市售可食用海产品在人体内的药代动力学研究：身体成分的潜在影响和对血糖控制的影响。
DOI：
10.3390/ph14080817
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发表时间：
2021-08-20
期刊：
影响因子：
--
通讯作者：
Bell C
中科院分区：
文献类型：
--
作者：
Ewell TR;Abbotts KSS;Williams NNB;Butterklee HM;Bomar MC;Harms KJ;Rebik JD;Mast SM;Akagi N;Dooley GP;Bell C
本研究的目的是描述和比较五种商业食用大麻产品的药代动力学，确定身体成分对药代动力学的影响，并根据流行病学表明大麻可能提供糖尿病保护，探索食用大麻对葡萄糖耐量的影响。七名经常吸食大麻的人在随机交叉设计中自行服用五种可食用产品;每种产品含有10毫克的δ-9-四氢大麻酚（THC）。在吸食大麻30分钟后，参与者饮用75克葡萄糖饮料。达到血浆THC浓度峰值的时间范围为35至90分钟;最大血浆THC浓度（Cmax）范围为3.2至5.5 ng/mL。检测到前20-30分钟期间产品之间血浆THC浓度的差异（p = 0.019）。确定了一些产品的身体组成和药代动力学参数之间的关系;然而，这些身体组成特征中没有一个与所有五种产品的药代动力学一致相关。与不含大麻的对照组相比，食用大麻对口服葡萄糖耐量没有影响（松田指数; p > 0.395）。市售可食用大麻产品在摄入后不久引起不同的血浆THC浓度，但似乎不会影响急性葡萄糖调节。这些数据可以让娱乐大麻使用者做出有关食用大麻摄入率的明智决定，并避免过量服用。
The purpose of the study was to describe and compare the pharmacokinetics of five commercial edible marijuana products, determine the influence of body composition on pharmacokinetics, and, in light of epidemiology suggesting marijuana may offer diabetes protection, explore the influence of edible marijuana on glucose tolerance. Seven regular users of marijuana self-administered five edible products in a randomized crossover design; each product contained 10 mg of delta-9-tetrahydrocannabinol (THC). Thirty minutes following marijuana ingestion, participants imbibed a 75 g glucose beverage. Time-to-peak plasma THC concentration ranged between 35 and 90 min; maximal plasma THC concentration (Cmax) ranged between 3.2 and 5.5 ng/mL. Differences between products in plasma THC concentration during the first 20–30 min were detected (p = 0.019). Relations were identified between body composition and pharmacokinetic parameters for some products; however, none of these body composition characteristics were consistently related to pharmacokinetics across all five of the products. Edible marijuana had no effect on oral glucose tolerance compared with a marijuana-free control (Matsuda Index; p > 0.395). Commercially available edible marijuana products evoke different plasma THC concentrations shortly after ingestion, but do not appear to influence acute glucose regulation. These data may allow recreational marijuana users to make informed decisions pertaining to rates of edible marijuana ingestion and avoid overdose.
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影响因子：
3.9
作者：
Lamsen, Mary Ross L.;Wang, Tiannan;Zhong, Qixin
通讯作者：
Zhong, Qixin
影响因子：
2.5
作者：
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作者：
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影响因子：
5.8
作者：
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通讯作者：
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影响因子：
2.5
作者：
Baggio, Michele;Chong, Alberto
通讯作者：
Chong, Alberto